CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer’s Disease Skin Fibroblasts

Published 2017 View Full Article

Authors

Keywords

CRISPR/Cas9, synergistic activation mediator, Alzheimer’s disease, amyloid precursor protein, β-amyloid, BACE1, presenilin, fibroblast, induced neuronal cells, γ-secretase processivity

Journal

Cell Reports

Volume 21, Issue 7, Pages 1727-1736

Publisher

Elsevier BV

Online

2017-11-15

DOI

10.1016/j.celrep.2017.10.075

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