Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

(2020) Arun Thiruvalluvan et al.   MOLECULAR CELL

AggreCount: An unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially-defined manner

(2020) Jacob Aaron Klickstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration

(2020) Amy Northrop et al.   MOLECULAR BIOLOGY OF THE CELL

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

HSP70 is a negative regulator of NLRP3 inflammasome activation

(2019) Pierre Martine et al.   Cell Death & Disease

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

The proteostasis network provides targets for neurodegeneration

(2019) Timothy Mark Newton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEURON

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases

(2019) Amanda K. Davis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

(2019) Anna E Masser et al.   eLife

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

(2019) Brígida R. Pinho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Proteostasis in the Context of Cellular and Organismal Health and Aging

(2018) Erica A Moehle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyglutamine Repeats in Neurodegenerative Diseases

(2018) Andrew P. Lieberman et al.   Annual Review of Pathology-Mechanisms of Disease

Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design

(2018) Mariarosaria Ferraro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the proteostasis network in Huntington’s disease

(2018) Tânia R. Soares et al.   AGEING RESEARCH REVIEWS

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells

(2018) Brígida R. Pinho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

(2017) Fatima Gasset-Rosa et al.   NEURON

Mutant Huntingtin Disrupts the Nuclear Pore Complex

(2017) Jonathan C. Grima et al.   NEURON

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

(2017) Andreas Neueder et al.   Scientific Reports

Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

(2016) Dig B. Mahat et al.   MOLECULAR CELL

Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders

(2016) Sara D. Reis et al.   MOLECULAR NEUROBIOLOGY

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

A model for handling cell stress

(2016) Laura Le Breton et al.   eLife

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

(2015) Eunhee Kim et al.   HUMAN MOLECULAR GENETICS

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response

(2015) Andrea V. Gómez et al.   PLoS One

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation

(2014) Elodie Monsellier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

(2014) Seiji Watanabe et al.   Molecular Brain

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

(2013) Zhuo Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correction: Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease

(2013) Magdalena Czeredys et al.   Frontiers in Molecular Neuroscience

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease

(2012) Mark S. Hipp et al.   JOURNAL OF CELL BIOLOGY

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

(2012) Adrienne M Wang et al.   Nature Chemical Biology

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

(2012) John Koren et al.   PLoS One

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease

(2011) I. V. Guzhova et al.   HUMAN MOLECULAR GENETICS

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

(2010) Gregor P. Lotz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

(2010) Derya R. Shimshek et al.   PLoS One

HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease

(2008) Joanna L. Howarth et al.   JOURNAL OF NEUROCHEMISTRY