Understanding How Coacervates Drive Reversible Small Molecule Reactions to Promote Molecular Complexity

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

(2021) William Peeples et al.   Nature Chemical Biology

Multiphase Complex Coacervate Droplets

(2020) Tiemei Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coacervates as models of membraneless organelles

(2020) N.Amy Yewdall et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Programmed spatial organization of biomacromolecules into discrete, coacervate-based protocells

(2020) Wiggert J. Altenburg et al.   Nature Communications

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates

(2019) Raghav R. Poudyal et al.   ACS Chemical Biology

Formation of Multiphase Complex Coacervates and Partitioning of Biomolecules within them

(2019) Gregory A. Mountain et al.   BIOMACROMOLECULES

Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry

(2018) Wylie Stroberg et al.   BIOPHYSICAL JOURNAL

Effect of small molecules on the phase behavior and coacervation of aqueous solutions of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrene sulfonate)

(2018) Shuyue Huang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates

(2018) Lu Li et al.   MACROMOLECULES

Compartmentalised RNA catalysis in membrane-free coacervate protocells

(2018) Björn Drobot et al.   Nature Communications

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

The wisdom of crowds: regulating cell function through condensed states of living matter

(2017) Simon Alberti   JOURNAL OF CELL SCIENCE

Partitioning of Small Molecules in Hydrogen-Bonding Complex Coacervates of Poly(acrylic acid) and Poly(ethylene glycol) or Pluronic Block Copolymer

(2017) Mengmeng Zhao et al.   MACROMOLECULES

Design of multi-phase dynamic chemical networks

(2017) Chenrui Chen et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combining Catalytic Microparticles with Droplets Formed by Phase Coexistence: Adsorption and Activity of Natural Clays at the Aqueous/Aqueous Interface

(2017) Fatma Pir Cakmak et al.   Scientific Reports

Sequestration of Methylene Blue into Polyelectrolyte Complex Coacervates

(2016) Mengmeng Zhao et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Nucleic acid-selective light-up fluorescent biosensors for ratiometric two-photon imaging of the viscosity of live cells and tissues

(2016) Dandan Li et al.   Chemical Science

Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling

(2015) Bradley W. Davis et al.   BIOPHYSICAL JOURNAL

Photocatalytic multiphase micro-droplet reactors based on complex coacervation

(2015) Kangle Lv et al.   CHEMICAL COMMUNICATIONS

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of Macromolecular Crowding Agents and Cosolutes with Small-Molecule Substrates: Effect on Horseradish Peroxidase Activity with Two Different Substrates

(2014) William M. Aumiller et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Coupled Enzyme Reactions Performed in Heterogeneous Reaction Media: Experiments and Modeling for Glucose Oxidase and Horseradish Peroxidase in a PEG/Citrate Aqueous Two-Phase System

(2014) William M. Aumiller et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets

(2014) Tony Z. Jia et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Enhanced Chemical Synthesis at Soft Interfaces: A Universal Reaction-Adsorption Mechanism in Microcompartments

(2014) Ali Fallah-Araghi et al.   PHYSICAL REVIEW LETTERS

Enhanced imine synthesis in water: from surfactant-mediated catalysis to host–guest mechanisms

(2013) Kamel Meguellati et al.   CHEMICAL COMMUNICATIONS

Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate

(2013) E. Sokolova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule uptake in membrane-free peptide/nucleotide protocells

(2013) T.-Y. Dora Tang et al.   Soft Matter

Systems of Creation: The Emergence of Life from Nonliving Matter

(2012) Stephen Mann   ACCOUNTS OF CHEMICAL RESEARCH

From Prelife to Life: How Chemical Kinetics Become Evolutionary Dynamics

(2012) Irene A. Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aqueous Phase Separation as a Possible Route to Compartmentalization of Biological Molecules

(2012) Christine D. Keating   ACCOUNTS OF CHEMICAL RESEARCH

Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer–nucleotide coacervate droplets

(2012) John Crosby et al.   CHEMICAL COMMUNICATIONS

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

RNA catalysis through compartmentalization

(2012) Christopher A. Strulson et al.   Nature Chemistry

Peptide–nucleotide microdroplets as a step towards a membrane-free protocell model

(2011) Shogo Koga et al.   Nature Chemistry

Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes

(2009) Kamel Meguellati et al.   ORGANIC LETTERS