Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase

Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro

(2021) Finny Varghese et al.   Viruses-Basel

Role of cyclins and cyclin-dependent kinases in pluripotent stem cells and their potential as a therapeutic target

(2020) Siwanon Jirawatnotai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Potential Antiviral Options against SARS-CoV-2 Infection

(2020) Aleksandr Ianevski et al.   Viruses-Basel

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

(2020) Yu-Jin Kim et al.   Viruses-Basel

The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors

(2019) Yu-Jin Kim et al.   ANTIVIRAL RESEARCH

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

(2018) Federico Lucantoni et al.   Oncotarget

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses

(2018) Masaharu Iwasaki et al.   PLoS Pathogens

Infection with flaviviruses requires BCLXL for cell survival

(2018) Tatsuya Suzuki et al.   PLoS Pathogens

Breaking Bad: How Viruses Subvert the Cell Cycle

(2018) Ying Fan et al.   Frontiers in Cellular and Infection Microbiology

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

(2017) Daria Bulanova et al.   Viruses-Basel

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

(2016) Finny S. Varghese et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

(2016) Sandra Söderholm et al.   ANTIVIRAL RESEARCH

BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics

(2016) R. S. Soderquist et al.   MOLECULAR CANCER THERAPEUTICS

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

(2015) Waseem Ahmad Siddiqui et al.   ARCHIVES OF TOXICOLOGY

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

(2015) Mai Nguyen et al.   BMC CANCER

Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression

(2015) C. Lutz et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Obatoclax Induces G1/G0-Phase Arrest via p38/p21waf1/Cip1Signaling Pathway in Human Esophageal Cancer Cells

(2014) Desheng Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells

(2014) Bruno Christian Koehler et al.   PLoS One

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

(2013) S. Beurlet et al.   BLOOD

Influenza A Virus NS1 Induces G0/G1 Cell Cycle Arrest by Inhibiting the Expression and Activity of RhoA Protein

(2013) W. Jiang et al.   JOURNAL OF VIROLOGY

Beyond Cell Death – Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro

(2013) Bruno Christian Koehler et al.   PLoS One

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737

(2011) Kenji Ishitsuka et al.   CANCER LETTERS

Thymidine kinase and cancer monitoring

(2011) Stefan Aufderklamm et al.   CANCER LETTERS

Influenza A Virus Replication Induces Cell Cycle Arrest in G0/G1 Phase

(2010) Y. He et al.   JOURNAL OF VIROLOGY

Rescue from Cloned cDNAs and In Vivo Characterization of Recombinant Pathogenic Romero and Live-Attenuated Candid #1 Strains of Junin Virus, the Causative Agent of Argentine Hemorrhagic Fever Disease

(2010) S. F. Emonet et al.   JOURNAL OF VIROLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

(2008) M. Konopleva et al.   CANCER RESEARCH

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

(2008) K. D. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA