Journal
CANCER LETTERS
Volume 316, Issue 1, Pages 6-10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.025
Keywords
Thymidine kinase 1; Cell proliferation; Cancer monitoring
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Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2 - located in mitochondria - is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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