Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
Authors
Keywords
-
Journal
Journal of Translational Medicine
Volume 19, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-12-07
DOI
10.1186/s12967-021-03165-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cell-programmed nutrient partitioning in the tumour microenvironment
- (2021) Bradley I. Reinfeld et al. NATURE
- Metabolic Control of Memory T-Cell Generation and Stemness
- (2021) Jana L. Raynor et al. Cold Spring Harbor Perspectives in Biology
- Infection Temperature Affects the Phenotype and Function of Chimeric Antigen Receptor T Cells Produced via Lentiviral Technology
- (2021) Xin Jin et al. Frontiers in Immunology
- Analysis of Factors Predicting Treatment Response of 254 Patients Who Received CD19-Targeted CAR-T Cell Therapy for Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL)
- (2020) Xian Zhang et al. BLOOD
- THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
- (2020) Chuang Sun et al. CANCER CELL
- Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
- (2020) Nina Dumauthioz et al. Cellular & Molecular Immunology
- Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation
- (2020) Richard T. Cattley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability
- (2020) Sonia Guedan et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8+ T cells
- (2020) Charlotte M. Mousset et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Efficacy and safety of anti-CD19 CAR T-cell therapy in 110 patients with B-cell acute lymphoblastic leukemia with high-risk features
- (2020) Xian Zhang et al. Blood Advances
- Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design
- (2020) Saba Ghassemi et al. Molecular Therapy-Methods & Clinical Development
- Manipulation of Glucose Availability to Boost Cancer Immunotherapies
- (2020) Federica Marchesi et al. Cancers
- IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity
- (2019) Darya Alizadeh et al. Cancer Immunology Research
- A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.
- (2019) Vivek Narayan et al. JOURNAL OF CLINICAL ONCOLOGY
- Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy
- (2019) Jaco A. C. van Bruggen et al. BLOOD
- The metabolic spectrum of memory T cells
- (2019) David O'Sullivan IMMUNOLOGY AND CELL BIOLOGY
- Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
- (2019) Luca Simula et al. PHARMACOLOGICAL RESEARCH
- PGC-1α activator–induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer
- (2019) Huan Wan et al. TUMORI
- Anti-CD19 Chimeric Antigen Receptor T Cells in Combination With Nivolumab Are Safe and Effective Against Relapsed/Refractory B-Cell Non-hodgkin Lymphoma
- (2019) Yaqing Cao et al. Frontiers in Oncology
- The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells
- (2019) Taisuke Kondo et al. CANCER RESEARCH
- Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
- (2019) Jun Wei et al. NATURE
- CRISPR/Cas9-mediated knockout of DGK improves anti-tumor activities of human T cells
- (2018) In-Young Jung et al. CANCER RESEARCH
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
- (2018) Ashley V. Menk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells
- (2018) Wenting Zheng et al. LEUKEMIA
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
- (2018) Ilenia Pacella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
- (2018) Jake S. O’Donnell et al. SEMINARS IN CANCER BIOLOGY
- IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
- (2018) Romy Loschinski et al. Oncotarget
- Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation
- (2018) Alvaro Teijeira et al. Cancer Immunology Research
- Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy
- (2018) Soumaya Kouidhi et al. Frontiers in Immunology
- Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma
- (2018) Concetta Quintarelli et al. OncoImmunology
- Targeting PIM Kinase with PD1 inhibition Improves Immunotherapeutic Antitumor T-cell Response
- (2018) Shilpak Chatterjee et al. CLINICAL CANCER RESEARCH
- A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells
- (2017) Ruihua Ma et al. NATURE CELL BIOLOGY
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
- (2017) Kenji Chamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mitochondrial dynamics in cancer and immune-surveillance
- (2017) Luca Simula et al. SEMINARS IN CANCER BIOLOGY
- PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells
- (2017) Jacob S. Bowers et al. Frontiers in Immunology
- Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
- (2016) M. Sabatino et al. BLOOD
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
- (2016) Michael D. Buck et al. CELL
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
- (2016) Noga Ron-Harel et al. Cell Metabolism
- Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy
- (2016) Madhusudhanan Sukumar et al. Cell Metabolism
- 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation
- (2016) Beom K Choi et al. Cellular & Molecular Immunology
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Constitutive Glycolytic Metabolism Supports CD8 + T Cell Effector Memory Differentiation during Viral Infection
- (2016) Anthony T. Phan et al. IMMUNITY
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
- (2016) Hu Zeng et al. IMMUNITY
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
- (2016) Peter J. Siska et al. JOURNAL OF IMMUNOLOGY
- Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
- (2016) Kaichao Feng et al. Science China-Life Sciences
- Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
- (2016) Eloah Rabello Suarez et al. Oncotarget
- Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity
- (2015) Yanhong Wu et al. BMC CANCER
- Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
- (2015) Zeguo Zhao et al. CANCER CELL
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo
- (2015) D Sommermeyer et al. LEUKEMIA
- T cell metabolic fitness in antitumor immunity
- (2015) Peter J. Siska et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
- (2014) S. Guedan et al. BLOOD
- Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy
- (2014) A. B. van der Waart et al. BLOOD
- Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
- (2014) J. G. Crompton et al. CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
- (2013) G. J. W. van der Windt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
- (2013) Liza B John et al. OncoImmunology
- Metabolic switching and fuel choice during T-cell differentiation and memory development
- (2012) Gerritje J. W. Windt et al. IMMUNOLOGICAL REVIEWS
- Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation
- (2012) E. H. Kim et al. JOURNAL OF IMMUNOLOGY
- OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+T cells
- (2012) Andreas A. Hombach et al. OncoImmunology
- Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
- (2011) Pablo J Fernandez-Marcos et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse
- (2011) Francesc Baixauli et al. EMBO JOURNAL
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
- (2011) Weiguo Cui et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Intracellular Signals of T Cell Costimulation
- (2010) Jianxun Song et al. Cellular & Molecular Immunology
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms
- (2010) Jiali Sun et al. MOLECULAR THERAPY
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search