Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer

Blocking podoplanin inhibits platelet activation and decreases cancer-associated venous thrombosis

(2021) Xia Wang et al.   THROMBOSIS RESEARCH

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

(2021) Nadim Tawil et al.   Blood Advances

Low dose Btk inhibitors selectively block platelet activation by CLEC-2

(2020) Phillip L.R. Nicolson et al.   HAEMATOLOGICA

Functional significance of the platelet immune receptors GPVI and CLEC-2

(2019) Julie Rayes et al.   JOURNAL OF CLINICAL INVESTIGATION

ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis

(2019) Vinita Yadav et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin

(2019) Katsue Suzuki-Inoue   BLOOD

Podoplanin promotes cancer-associated thrombosis and contributes to the unfavorable overall survival in an ectopic xenograft mouse model of oral cancer

(2019) Hsing-Ying Lee et al.   Biomedical Journal

Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners fromin uteroto adulthood

(2017) K. Suzuki-Inoue et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice

(2017) T. Shirai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Incidence and Timing of Thromboembolic Events in Patients With Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

(2017) Patricia S. Greco et al.   OBSTETRICS AND GYNECOLOGY

Reciprocal links between venous thromboembolism, coagulation factors and ovarian cancer progression

(2017) Nathalie Swier et al.   THROMBOSIS RESEARCH

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis

(2017) He Meng et al.   Arthritis & Rheumatology

Podoplanin-mediated TGF-β-induced epithelial-mesenchymal transition and its correlation with bHLH transcription factor DEC in TE-11 cells

(2016) YUNYAN WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer

(2016) Carlota Claussen et al.   THROMBOSIS RESEARCH

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

(2015) K. L. Lowe et al.   BLOOD

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

(2015) Jessica R. Hitchcock et al.   JOURNAL OF CLINICAL INVESTIGATION

Thrombosis in ovarian cancer: a case control study

(2014) R L Metcalf et al.   BRITISH JOURNAL OF CANCER

Venous Thromboembolism in Advanced Ovarian Cancer Patients Undergoing Frontline Adjuvant Chemotherapy

(2014) Alok Pant et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Epidemiology of cancer-associated venous thrombosis

(2013) J. F. Timp et al.   BLOOD

Venous thromboembolism in ovarian cancer: incidence, risk factors and impact on survival

(2013) Feras Abu Saadeh et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

(2013) Paul R. Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of ovarian tumor characteristics on venous thromboembolic risk

(2013) Arvind Bakhru   Journal of Gynecologic Oncology

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Venous thromboembolism (VTE) rates following the implementation of extended duration prophylaxis for patients undergoing surgery for gynecologic malignancies

(2012) Kathleen M. Schmeler et al.   GYNECOLOGIC ONCOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelet CLEC-2 and podoplanin in cancer metastasis

(2012) Kate L. Lowe et al.   THROMBOSIS RESEARCH

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

Novel platelet activation receptor CLEC-2: from discovery to prospects

(2011) K. SUZUKI-INOUE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy

(2010) Gregory C. Connolly et al.   THROMBOSIS RESEARCH

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

Deep venous thrombosis in gynecological oncology: Incidence and clinical symptoms study

(2009) Joseph T. Santoso et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

When ‘never-events’ occur despite adherence to clinical guidelines: The case of venous thromboembolism in clear cell cancer of the ovary compared with other epithelial histologic subtypes

(2009) Linda R. Duska et al.   GYNECOLOGIC ONCOLOGY

Incidence of Venous Thromboembolism in Patients With Ovarian Cancer Undergoing Platinum/Paclitaxel–Containing First-Line Chemotherapy: An Exploratory Analysis by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group

(2008) Christina Fotopoulou et al.   JOURNAL OF CLINICAL ONCOLOGY