Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry

The Effects of Sodium Ions on Ligand Binding and Conformational States of G Protein-Coupled Receptors—Insights from Mass Spectrometry

(2021) Mark T. Agasid et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

High-Resolution Native Mass Spectrometry

(2021) Sem Tamara et al.   CHEMICAL REVIEWS

Protein–Small Molecule Interactions in Native Mass Spectrometry

(2021) Jack L. Bennett et al.   CHEMICAL REVIEWS

Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

(2020) Giang T. H. Nguyen et al.   ANALYTICAL CHEMISTRY

Studying biomolecular folding and binding using temperature-jump mass spectrometry

(2020) Adrien Marchand et al.   Nature Communications

Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

(2020) Joseph Gault et al.   NATURE METHODS

Mass Spectrometry-Based Shotgun Glycomics for Discovery of Natural Ligands of Glycan-Binding Proteins

(2020) Heajin Park et al.   ANALYTICAL CHEMISTRY

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand–Protein Binding Affinities

(2019) Giang T. H. Nguyen et al.   ACS Central Science

SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information

(2019) Kai Dührkop et al.   NATURE METHODS

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Determining Membrane Protein–Lipid Binding Thermodynamics Using Native Mass Spectrometry

(2016) Xiao Cong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-resolution mass spectrometry of small molecules bound to membrane proteins

(2016) Joseph Gault et al.   NATURE METHODS

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

New natural product carbonic anhydrase inhibitors incorporating phenol moieties

(2015) Anastasia Karioti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry

(2015) Michael B. Cammarata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Revealing Ligand Binding Sites and Quantifying Subunit Variants of Noncovalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment

(2014) Huilin Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Boundaries of Mass Resolution in Native Mass Spectrometry

(2014) Philip Lössl et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Identifying Carbohydrate Ligands of a Norovirus P Particle using a Catch and Release Electrospray Ionization Mass Spectrometry Assay

(2013) Ling Han et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Applications of a Catch and Release Electrospray Ionization Mass Spectrometry Assay for Carbohydrate Library Screening

(2011) Amr El-Hawiet et al.   ANALYTICAL CHEMISTRY

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Carbonic anhydrase inhibitors:in vitroinhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids

(2011) Derya Ekinci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I–XIV with a series of natural product polyphenols and phenolic acids

(2010) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors: Inhibition of Human Erythrocyte Isozymes I and II with a Series of Phenolic Acids

(2010) S. Beyza Öztürk Sarıkaya et al.   Chemical Biology & Drug Design

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY