The Effects of Sodium Ions on Ligand Binding and Conformational States of G Protein-Coupled Receptors—Insights from Mass Spectrometry

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

(2020) Leonhard H. Urner et al.   Nature Communications

Enhancing the Signaling of GPCRs via Orthosteric Ions

(2020) H. C. Stephen Chan et al.   ACS Central Science

Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

(2020) Joseph Gault et al.   NATURE METHODS

New Binding Sites, New Opportunities for GPCR Drug Discovery

(2019) H.C. Stephen Chan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand–Protein Binding Affinities

(2019) Giang T. H. Nguyen et al.   ACS Central Science

Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry

(2019) Jani Reddy Bolla et al.   Annual Review of Biochemistry

Ligand-Dependent Sodium Ion Dynamics within the A2A Adenosine Receptor: A Molecular Dynamics Study

(2019) Xiaohu Hu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?

(2019) Arnault Massink et al.   MEDICINAL RESEARCH REVIEWS

Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation

(2019) Xiaohu Hu et al.   BIOPHYSICAL JOURNAL

Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor

(2018) Kelly J. Culhane et al.   ACS Chemical Biology

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

Mass spectrometry-enabled structural biology of membrane proteins

(2018) Antonio N. Calabrese et al.   METHODS

Lipid binding attenuates channel closure of the outer membrane protein OmpF

(2018) Idlir Liko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

(2018) Kate L. White et al.   STRUCTURE

Intracellular Transfer of Na + in an Active-State G-Protein-Coupled Receptor

(2018) Owen N. Vickery et al.   STRUCTURE

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry

(2017) Philipp Fronik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents

(2017) Anna C. Susa et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structure of the full-length glucagon class B G-protein-coupled receptor

(2017) Haonan Zhang et al.   NATURE

Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

(2017) Hsin-Yung Yen et al.   Science Advances

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of purification conditions and history on A 2A adenosine receptor activity: The role of CHAPS and lipids

(2016) Andrea N. Naranjo et al.   PROTEIN EXPRESSION AND PURIFICATION

Mass Spectrometry of Protein Complexes: From Origins to Applications

(2015) Shahid Mehmood et al.   Annual Review of Physical Chemistry

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs

(2012) Nivedita Mitra et al.   ACS Chemical Biology

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

(2011) Andrew S. Doré et al.   STRUCTURE