Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation

Zanthoxylum alatum Roxb. seed extract ameliorates stress aggravated DSS-induced ulcerative colitis in mice: Plausible role on NF-κB signaling axis

(2021) Malayamarutham Kalyankumarraju et al.   JOURNAL OF ETHNOPHARMACOLOGY

Current Perspectives on Gut Microbiome Dysbiosis and Depression

(2020) Alexander Capuco et al.   ADVANCES IN THERAPY

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

(2020) Xiaoxia Ye et al.   Journal of Neuroinflammation

Amelioration of Repeated Restraint Stress-Induced Behavioral Deficits and Hippocampal Anomalies with Taurine Treatment in Mice

(2020) Ashok Jangra et al.   NEUROCHEMICAL RESEARCH

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence

(2020) Surya Narayan Pandey et al.   PSYCHOPHARMACOLOGY

Validation of Chronic Restraint Stress Model in Young Adult Rats for the Study of Depression Using Longitudinal Multimodal MR Imaging

(2020) Bhedita J. Seewoo et al.   eNeuro

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

(2020) Sahabuddin Ahmed et al.   APOPTOSIS

Stress and signaling pathways regulating autophagy: From behavioral models to psychiatric disorders

(2020) Bruna C. Pierone et al.   EXPERIMENTAL NEUROLOGY

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

(2020) Ying Han et al.   Frontiers in Cellular Neuroscience

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

(2019) Rui Zuo et al.   STEM CELLS

Predictable chronic mild stress promotes recovery from LPS-induced depression

(2019) Ruili Dang et al.   Molecular Brain

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice

(2019) Ji Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

(2019) Aimée Parker et al.   Gut Microbes

Animal models of major depression: drawbacks and challenges

(2019) Barbara Planchez et al.   JOURNAL OF NEURAL TRANSMISSION

Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine

(2019) Sayan Ghosh et al.   CELLULAR SIGNALLING

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments

(2018) Yong-Ku Kim et al.   Current Neuropharmacology

Different effects of immune stimulation on chronic unpredictable mild stress-induced anxiety- and depression-like behaviors depending on timing of stimulation

(2018) Jiangyan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation

(2018) Ksenia Musaelyan et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

(2018) Xinghua Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nyctanthes arbor-tristis leaf extract ameliorates hyperlipidemia- and hyperglycemia-associated nephrotoxicity by improving anti-oxidant and anti-inflammatory status in high-fat diet–streptozotocin-induced diabetic rats

(2018) Sayed Adam Mousum et al.   INFLAMMOPHARMACOLOGY

Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation

(2018) Yuguang Zhao et al.   Redox Biology

Andrographolide Protects PC12 Cells Against β-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway

(2018) Lili Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model

(2018) Ying Han et al.   Neuroscience Bulletin

TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation

(2018) Giselli Scaini et al.   NEUROPSYCHOPHARMACOLOGY

Increased thioredoxin-interacting protein in brain of mice exposed to chronic stress

(2018) Hong Zhou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1

(2018) Priyansha Choubey et al.   PSYCHOPHARMACOLOGY

From Gut to Brain: Alteration in Inflammation Markers in the Brain of Dextran Sodium Sulfate-induced Colitis Model Mice

(2018) Jongho Do et al.   Clinical Psychopharmacology and Neuroscience

Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system

(2017) Gema Tarrasón et al.   EXPERIMENTAL DERMATOLOGY

Single-Prolonged-Stress-Induced Changes in Autophagy-Related Proteins Beclin-1, LC3, and p62 in the Medial Prefrontal Cortex of Rats with Post-traumatic Stress Disorder

(2017) Shilei Zheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse

(2017) Debra L Hickman   LAB ANIMAL

Cognitive deficits induced by combined exposure of stress and alcohol mediated through oxidative stress-PARP pathway in the hippocampus

(2017) Rajat Pant et al.   NEUROSCIENCE LETTERS

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

(2017) Manish Kumar Jeengar et al.   Scientific Reports

Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation

(2016) Ashok Jangra et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice

(2016) Ashok Jangra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

(2016) Yvonne Couch et al.   Journal of Neuroinflammation

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

(2016) G B Rogers et al.   MOLECULAR PSYCHIATRY

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

(2016) E Bouvier et al.   MOLECULAR PSYCHIATRY

The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction

(2016)   MOLECULES AND CELLS

Effects of (−)-Sesamin on Chronic Stress-Induced Anxiety Disorders in Mice

(2016) Ting Ting Zhao et al.   NEUROCHEMICAL RESEARCH

Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus

(2016) Mohit Kwatra et al.   NEUROCHEMICAL RESEARCH

Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons

(2016) Carmen R. Sunico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis

(2015) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: Reversibility by imipramine and pentoxifylline

(2014) Al-Shaimaa A. Elgarf et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux

(2014) Hong-Feng Gu et al.   PLoS One

Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms

(2014) Matthew Owens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

(2014) Arnaud Francois et al.   Molecular Brain

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Chronic Stress-Induced Changes in Pro-Inflammatory Cytokines and Spinal Glia Markers in the Rat: A Time Course Study

(2012) Viktoriya Golovatscka et al.   NEUROIMMUNOMODULATION

Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex

(2012) Shuichi Chiba et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus

(2009) A.M. Espinosa-Oliva et al.   NEUROBIOLOGY OF AGING