NOD2 Stimulation by Staphylococcus aureus-Derived Peptidoglycan Is Boosted by Toll-Like Receptor 2 Costimulation with Lipoproteins in Dendritic Cells

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

(2014) J. G. Magalhaes et al.   JOURNAL OF IMMUNOLOGY

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

(2011) E. M. Fernandez et al.   GUT

Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers

(2011) Janaki K. Iyer et al.   JOURNAL OF IMMUNOLOGY

Nod2 Downregulates TLR2/1 Mediated IL1β Gene Expression in Mouse Peritoneal Macrophages

(2011) Yogesh Dahiya et al.   PLoS One

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals

(2010) Thomas Volz et al.   FASEB JOURNAL

Intestinal dendritic cells

(2010) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Staphylococcal Peptidoglycan Co-Localizes with Nod2 and TLR2 and Activates Innate Immune Response via Both Receptors in Primary Murine Keratinocytes

(2010) Maria Anna Müller-Anstett et al.   PLoS One

Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells

(2009) I D Iliev et al.   GUT

The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses

(2009) Warren Strober   IMMUNITY

Lipoproteins in Staphylococcus aureus Mediate Inflammation by TLR2 and Iron-Dependent Growth In Vivo

(2009) M. Schmaler et al.   JOURNAL OF IMMUNOLOGY

TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

(2008) Ulrich Zähringer et al.   IMMUNOBIOLOGY

A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells

(2008) Mizuho Natsuka et al.   Innate Immunity

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

(2008) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology

Role of mucosal dendritic cells in inflammatory bowel disease

(2008) Jan Hendrik Niess   WORLD JOURNAL OF GASTROENTEROLOGY