The beta 2 ‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Adipocyte Browning in Response to Trauma

(2021) Craig Porter   SHOCK

Anabolic and lipolytic actions of beta 2 ‐agonists in humans and antidoping challenges

(2020) Morten Hostrup et al.   Drug Testing and Analysis

Treatment with a β-2-adrenoceptor agonist stimulates glucose uptake in skeletal muscle and improves glucose homeostasis, insulin resistance and hepatic steatosis in mice with diet-induced obesity

(2020) Anastasia Kalinovich et al.   DIABETOLOGIA

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

Beta2-agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint power output but not muscle force during 11 weeks of resistance training in young men

(2020) Søren Jessen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

(2019) Magdalena Koziczak-Holbro et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Beta2 -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular protein kinase A-signalling at therapeutic inhaled doses

(2019) Morten Hostrup et al.   Drug Testing and Analysis

Beta 2 ‐adrenergic agonist clenbuterol increases energy expenditure and fat oxidation, and induces mTOR phosphorylation in skeletal muscle of young healthy men

(2019) Søren Jessen et al.   Drug Testing and Analysis

β-2 Agonists as Misusing Drugs? Assessment of both Clenbuterol- and Salbutamol-related European Medicines Agency Pharmacovigilance Database Reports

(2018) Giulia Milano et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Long-Acting β2-Agonists in Asthma: Enantioselective Safety Studies are Needed

(2018) Glenn A. Jacobson et al.   DRUG SAFETY

Beta2 -adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men

(2018) Morten Hostrup et al.   JOURNAL OF PHYSIOLOGY-LONDON

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease

(2018) Dwight D. Koeberl et al.   MOLECULAR THERAPY

Hypertrophic effect of inhaled beta2 -agonist with and without concurrent exercise training: A randomized controlled trial

(2018) S. Jessen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Progress and challenges in anti-obesity pharmacotherapy

(2018) Daniel H Bessesen et al.   Lancet Diabetes & Endocrinology

Genetic variant in the β2 -Adrenergic receptor (Arg16Gly) influences fat free mass, muscle strength, and motor unit behavior in young men

(2018) Nathaniel D.M. Jenkins et al.   EXPERIMENTAL PHYSIOLOGY

Change of skeletal muscle mass in patients with pheochromocytoma

(2018) Seung Hun Lee et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETES CARE

β 2-Agonist Induces Net Leg Glucose Uptake and Free Fatty Acid Release at Rest but Not During Exercise in Young Men

(2018) Johan Onslev et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity Pathogenesis: An Endocrine Society Scientific Statement

(2017) Michael W Schwartz et al.   ENDOCRINE REVIEWS

Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men

(2017) Johan Onslev et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Quantification of UCP1 function in human brown adipose tissue

(2017) Craig Porter   Adipocyte

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

(2017) Robert B. Cameron et al.   Scientific Reports

Effect of formoterol, a long-acting β2-adrenergic agonist, on muscle strength and power output, metabolism, and fatigue during maximal sprinting in men

(2016) Anders Kalsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function

(2016) Craig Porter et al.   Cell Metabolism

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis

(2016) Kana Ohyama et al.   DIABETES

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma

(2016) Laurent Vergnes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rhabdomyolysis Secondary to Clenbuterol Use and Exercise

(2016) Nicole M. Grimmer et al.   JOURNAL OF EMERGENCY MEDICINE

The metabolic stress response to burn trauma: current understanding and therapies

(2016) Craig Porter et al.   LANCET

Inhaled Beta2-Agonist Increases Power Output and Glycolysis during Sprinting in Men

(2016) ANDERS KALSEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake

(2016) David Polidori et al.   Obesity

Towards Leanness by ‘Feeding’ a Novel Thermogenic Pathway?

(2016) Jens Lund et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size

(2016) Adam Hagg et al.   Scientific Reports

Pharmacokinetics of Oral and Inhaled Terbutaline after Exercise in Trained Men

(2016) Anders Dyreborg et al.   Frontiers in Pharmacology

Evaluation of the Glutamine 27 Glutamic Acid Polymorphism in the Adrenoceptor β2 Surface Gene on Obesity and Metabolic Phenotypes in Taiwan

(2016) Tun-Jen Hsiao et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men

(2015) Morten Hostrup et al.   JOURNAL OF APPLIED PHYSIOLOGY

Formoterol, a Highly β2-Selective Agonist, Induces Gender-Dimorphic Whole Body Leucine Metabolism in Humans

(2015) Paul Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes

(2015) Colette N. Miller et al.   PLoS One

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men

(2014) Morten Hostrup et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Beta agonists in livestock feed: Status, health concerns, and international trade

(2014) T. J. Centner et al.   JOURNAL OF ANIMAL SCIENCE

Effect of inhaled terbutaline on substrate utilization and 300-kcal time trial performance

(2014) Anders Kalsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

β2-Adrenergic stimulation enhances Ca2+release and contractile properties of skeletal muscles, and counteracts exercise-induced reductions in Na+-K+-ATPaseVmaxin trained men

(2014) M. Hostrup et al.   JOURNAL OF PHYSIOLOGY-LONDON

Improving long-term weight loss maintenance: Can we do it?

(2014) George A. Bray et al.   Obesity

Association of Gln27Glu and Arg16Gly Polymorphisms in Beta2-Adrenergic Receptor Gene with Obesity Susceptibility: A Meta-Analysis

(2014) Hongxiu Zhang et al.   PLoS One

White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma

(2013) Andrea Frontini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum

(2013) Brandy L. Akin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Energy Metabolism in Pheochromocytoma

(2013) O. Petrák et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Descriptive Study of Adverse Events from Clenbuterol Misuse and Abuse for Weight Loss and Bodybuilding

(2013) Henry A. Spiller et al.   Substance Abuse

Systemic  -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans

(2012) M. J. Vosselman et al.   DIABETES

Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men

(2012) P Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Urine and Serum Concentrations of Inhaled and Oral Terbutaline

(2012) J. Elers et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor

(2012) Daniel C. Andersson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phospholamban phosphorylation increases the passive calcium leak from cardiac sarcoplasmic reticulum

(2012) Roozbeh Aschar-Sobbi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Human-Specific SNP in Obesity Genes, Adrenergic Receptor Beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during Primate Evolution

(2012) Akiko Takenaka et al.   PLoS One

Effects of β2-adrenergic stimulation on exercise capacity in normal subjects

(2011) S. P. Beloka et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Association of adrenergic receptor gene polymorphisms with adolescent obesity in Taiwan

(2011) Yi-Chun Chou et al.   PEDIATRICS INTERNATIONAL

Challenges in β3-adrenoceptor agonist drug development

(2011) Jonathan R. S. Arch   Therapeutic Advances in Endocrinology and Metabolism

The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors

(2010) Jillian G Baker   BRITISH JOURNAL OF PHARMACOLOGY

Gender Differences in Pediatric Burn Patients

(2009) Marc G. Jeschke et al.   ANNALS OF SURGERY

Novel role for β-adrenergic signalling in skeletal muscle growth, development and regeneration

(2009) James G Ryall et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity

(2009) S. L. J. Wijers et al.   Obesity Reviews

Salbutamol intake and substrate oxidation during submaximal exercise

(2008) A. Arlettaz et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Can β Agonists Cause Dilated Cardiomyopathy?

(2008) Anwar S. Choudhary et al.   Heart Lung and Circulation

Clenbuterol Increases Lean Muscle Mass but Not Endurance in Patients With Chronic Heart Failure

(2008) Gayathri Kamalakkannan et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE