Terminal complexes of the complement system: new structural insights and their relevance to function

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

Complementing the inflammasome

(2016) Martha Triantafilou et al.   IMMUNOLOGY

Lipid rafts in immune signalling: current progress and future perspective

(2016) Pallavi Varshney et al.   IMMUNOLOGY

Complement Membrane Attack and Tumorigenesis

(2016) Laurence D. Towner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Structure of the poly-C9 component of the complement membrane attack complex

(2016) Natalya V. Dudkina et al.   Nature Communications

Structural basis of complement membrane attack complex formation

(2016) Marina Serna et al.   Nature Communications

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

(2016) Thomas H. Sharp et al.   Cell Reports

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9

(2015) Dan Stratton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural determinants of protein partitioning into ordered membrane domains and lipid rafts

(2015) Joseph Helmuth Lorent et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+NIK+signalosome on Rab5+endosomes

(2015) Dan Jane-wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Distinct localization of the complement C5b-9 complex on Gram-positive bacteria

(2013) Evelien T. M. Berends et al.   CELLULAR MICROBIOLOGY

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

(2013) Steven Johnson et al.   Cell Reports

Caveolin-1 and Dynamin-2 Are Essential for Removal of the Complement C5b-9 Complex via Endocytosis

(2012) Oren Moskovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

(2012) Michael A. Hadders et al.   Cell Reports

The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

(2012) Kelley J. Dowd et al.   PLoS Pathogens

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers

(2011) Paul V. Beum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Membrane attack by complement: the assembly and biology of terminal complement complexes

(2011) Cosmin A. Tegla et al.   IMMUNOLOGIC RESEARCH

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement

(2011) Leslie L. Lovelace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization and Pore Formation by Equinatoxin II Inhibit Endocytosis and Lead to Plasma Membrane Reorganization

(2011) Ana J. García-Sáez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8α and C9

(2011) Stephanie E. Wickham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sublytic C5b-9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy-1 nephritis through TRAF6-mediated PI3K-dependent Akt1 activation

(2011) Wen Qiu et al.   JOURNAL OF PATHOLOGY

Intermedilysin-Receptor Interactions during Assembly of the Pore Complex

(2009) Stephanie LaChapelle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59

(2009) Timothy R. Hughes et al.   MOLECULAR IMMUNOLOGY

The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis

(2009) F. Corallini et al.   RHEUMATOLOGY