Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation

Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses

(2016) Jing He et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane

(2015) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles

(2015) Raphaël Gaudin et al.   Nature Communications

A role for Rab27 in neutrophil chemotaxis and lung recruitment

(2014) Rajesh K Singh et al.   BMC CELL BIOLOGY

The role of Rab27a in the regulation of neutrophil function

(2014) Sergio D. Catz   CELLULAR MICROBIOLOGY

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Comparison of Proteins Expressed on Secretory Vesicle Membranes and Plasma Membranes of Human Neutrophils

(2014) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Munc13-4 Regulates Granule Secretion in Human Neutrophils

(2014) C. Pivot-Pajot et al.   JOURNAL OF IMMUNOLOGY

High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival

(2014) Qingqing Wang et al.   MEDICAL ONCOLOGY

Rab27a Is Essential for the Formation of Neutrophil Extracellular Traps (NETs) in Neutrophil-Like Differentiated HL60 Cells

(2014) Tatsumi Kawakami et al.   PLoS One

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

(2014) Meixiao Shen et al.   PLoS One

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

The Role of Neutrophil Myeloperoxidase in Models of Lung Tumor Development

(2014) Amy Rymaszewski et al.   Cancers

Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

(2013) Y. Wang et al.   CANCER RESEARCH

A Network of Interactions Enables CCM3 and STK24 to Coordinate UNC13D-Driven Vesicle Exocytosis in Neutrophils

(2013) Yong Zhang et al.   DEVELOPMENTAL CELL

Depletion of blood neutrophils from patients with sepsis: treatment for the future?

(2013) Sion M. Lewis et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes

(2013) S. E. Reed et al.   JOURNAL OF CELL SCIENCE

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells

(2013) Puneet Khandelwal et al.   MOLECULAR BIOLOGY OF THE CELL

GM-CSF as a therapeutic target in inflammatory diseases

(2013) Annemarie van Nieuwenhuijze et al.   MOLECULAR IMMUNOLOGY

Inhibition of Neutrophil Exocytosis Ameliorates Acute Lung Injury in Rats

(2013) Silvia M. Uriarte et al.   SHOCK

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

(2013) Mitsunori Fukuda   TRAFFIC

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Rab11 proteins in health and disease

(2012) Eoin E. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

(2012) R. K. Singh et al.   JOURNAL OF CELL SCIENCE

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis

(2012) S. Zografou et al.   JOURNAL OF CELL SCIENCE

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein

(2012) Jennifer L. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular basis of leukocyte recruitment and its deficiencies

(2012) Sarah Schmidt et al.   MOLECULAR IMMUNOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Increased Intratumoral Neutrophil in Colorectal Carcinomas Correlates Closely with Malignant Phenotype and Predicts Patients' Adverse Prognosis

(2012) Hui-Lan Rao et al.   PLoS One

Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

(2012) Wei-Wei Dong   WORLD JOURNAL OF GASTROENTEROLOGY

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis

(2011) K. Zen et al.   BLOOD

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Increased Survival and Reduced Neutrophil Infiltration of the Liver in Rab27a- but Not Munc13-4-Deficient Mice in Lipopolysaccharide-Induced Systemic Inflammation

(2011) Jennifer L. Johnson et al.   INFECTION AND IMMUNITY

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Involvement of Rab3A in Vesicle Priming During Exocytosis: Interaction with Munc13-1 and Munc18-1

(2011) Chien-Chang Huang et al.   TRAFFIC

Endosome–lysosome fusion: Figure 1

(2010) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

(2010) Q. Ren et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Human neutrophil granules and secretory vesicles

(2010) Niels Borregaard et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Intracellular location of syntaxin 7 in human neutrophils

(2010) Li-xin Xie et al.   IMMUNOLOGY LETTERS

Munc13-4 Restricts Motility of Rab27a-expressing Vesicles to Facilitate Lipopolysaccharide-induced Priming of Exocytosis in Neutrophils

(2010) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

(2010) Yi-Wei Li et al.   JOURNAL OF HEPATOLOGY

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF

(2009) Luigi Dolcetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis

(2009) Kenji Sugawara et al.   GENES TO CELLS

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

(2009) Hanne Krogh Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

DNase I Inhibits a Late Phase of Reactive Oxygen Species Production in Neutrophils

(2009) Daniela B. Munafo et al.   Journal of Innate Immunity

A Fluorescently Tagged C-Terminal Fragment of p47phox Detects NADPH Oxidase Dynamics during Phagocytosis

(2009) Xing Jun Li et al.   MOLECULAR BIOLOGY OF THE CELL

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bringing up the rear: defining the roles of the uropod

(2009) Francisco Sánchez-Madrid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab35 Controls Actin Bundling by Recruiting Fascin as an Effector Protein

(2009) J. Zhang et al.   SCIENCE

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

(2009) Jennifer L. Johnson et al.   TRAFFIC

Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling

(2008) Troy Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice

(2008) Viktor Brovkovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Membrane traffic in the secretory pathway

(2008) M. Fukuda   CELLULAR AND MOLECULAR LIFE SCIENCES

Rab35 and Its GAP EPI64C in T Cells Regulate Receptor Recycling and Immunological Synapse Formation

(2008) Genaro Patino-Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II

(2008) J.-S. Wang et al.   MOLECULAR CANCER RESEARCH

Rab14 Regulates Apical Targeting in Polarized Epithelial Cells

(2008) Khameeka N. Kitt et al.   TRAFFIC

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules

(2008) Agnieszka A. Brzezinska et al.   TRAFFIC