Site-Specific Stabilization and Destabilization of α Helical Peptides upon Phosphorylation and O-GlcNAcylation

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

(2021) Carolina Alquezar et al.   Frontiers in Neurology

Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease

(2021) Songzhe He et al.   ACS Chemical Neuroscience

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

(2021) François-Xavier Cantrelle et al.   Frontiers in Molecular Neuroscience

Effect of Phosphorylation and O-GlcNAcylation on Proline-Rich Domains of Tau

(2020) Lata Rani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

(2018) Sean M. Deguire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTMD: A Database of Human Disease-associated Post-translational Modifications

(2018) Haodong Xu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

AMBER and CHARMM Force Fields Inconsistently Portray the Microscopic Details of Phosphorylation

(2018) Jiří Vymětal et al.   Journal of Chemical Theory and Computation

Phosphorylation versus O-GlcNAcylation: Computational Insights into the Differential Influences of the Two Competitive Post-Translational Modifications

(2017) Lata Rani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

(2015) Nicholas P. Marotta et al.   Nature Chemistry

OGlcNAcylation and Phosphorylation Have Similar Structural Effects in α-Helices: Post-Translational Modifications as Inducible Start and Stop Signals in α-Helices, with Greater Structural Effects on Threonine Modification

(2014) Michael B. Elbaum et al.   BIOCHEMISTRY

OGlcNAcylation and Phosphorylation Have Opposing Structural Effects in tau: Phosphothreonine Induces Particular Conformational Order

(2014) Michael A. Brister et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach

(2013) Matthias Michalek et al.   BIOPHYSICAL JOURNAL

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

linking metabolism to epigenetics through O-GlcNAcylation

(2012) John A. Hanover et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling

(2011) Olgun Guvench et al.   Journal of Chemical Theory and Computation

Influence of Solvent and Intramolecular Hydrogen Bonding on the Conformational Properties of O-Linked Glycopeptides

(2011) Sairam S. Mallajosyula et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions

(2010) Avijit Chakrabartty et al.   PROTEIN SCIENCE

O-GlcNAc signaling: a metabolic link between diabetes and cancer?

(2010) C. Slawson et al.   TRENDS IN BIOCHEMICAL SCIENCES

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Insights into the Geometrical Features Underlying β-O-GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone

(2009) Alberto Fernández-Tejada et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regulation of Calcium/Calmodulin-dependent Kinase IV byO-GlcNAc Modification

(2009) Wagner B. Dias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA