CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Sepsis-Associated Encephalopathy: From Delirium to Dementia?

(2020) Ha-Yeun Chung et al.   Journal of Clinical Medicine

Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway

(2020) Xinqi Zhuang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

(2020) Tao Li et al.   MOLECULAR IMMUNOLOGY

CXCR5 Knockdown Attenuates Hippocampal Neurogenesis Deficits and Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

(2020) Yanan Shen et al.   NEUROSCIENCE

CXCL13 Is Involved in the Lipopolysaccharide-Induced Hyperpermeability of Umbilical Vein Endothelial Cells

(2020) Wen Chen et al.   INFLAMMATION

Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis

(2020) Madhu Sudhana Saddala et al.   Biomedicines

Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor

(2020) Bin Mei et al.   BRAIN BEHAVIOR AND IMMUNITY

Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells

(2020) Anton Lennikov et al.   LABORATORY INVESTIGATION

Attractylone attenuates sepsis-associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation

(2019) Mi Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation

(2019) Yin Cao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of the RAC1/MLK3/p38 Signaling Pathway by β-Elemene Alleviates Sepsis-Associated Encephalopathy in Mice

(2019) Cailong Pan et al.   Frontiers in Neuroscience

Systemic infection and microglia activation: a prospective postmortem study in sepsis patients

(2019) D. Westhoff et al.   Immunity & Ageing

Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis‐associated encephalopathy by immunity‐related GTPase M1

(2019) Rui‐Xi Zhou et al.   CNS Neuroscience & Therapeutics

Recombinant CC16 regulates inflammation, oxidative stress, apoptosis and autophagy via the inhibition of the p38MAPK signaling pathway in the brain of neonatal rats with sepsis

(2019) Ruixi Zhou et al.   BRAIN RESEARCH

Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis

(2018) Nurdan Bedirli et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways

(2018) Peng Li et al.   LIFE SCIENCES

Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients

(2018) Yu-chang Wang et al.   MEDICINE

Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy

(2018) Johannes Ehler et al.   NEUROSCIENCE LETTERS

Chemokine CXCL13 activates p38 MAPK in the trigeminal ganglion after infraorbital nerve injury

(2017) Qian Zhang et al.   INFLAMMATION

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

(2017) Yingli He et al.   JOURNAL OF CELL BIOLOGY

Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1–independent autophagy in mice

(2017) Yinjiao Li et al.   JOURNAL OF SURGICAL RESEARCH

Minocycline Prevents the Impairment of Hippocampal Long-Term Potentiation in the Septic Mouse

(2017) Koji Hoshino et al.   SHOCK

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

(2017) Stephen J. Kuperberg et al.   Frontiers in Immunology

Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy

(2016) Wenyu Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling

(2016) Taeyeop Park et al.   Journal of Neuroinflammation

Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats

(2016) Ruohan Li et al.   NEUROCHEMICAL RESEARCH

CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain

(2016) Xiao-Bo Wu et al.   Scientific Reports

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis

(2015) YunJie Su et al.   Journal of Neuroinflammation

A targeted real-time early warning score (TREWScore) for septic shock

(2015) Katharine E. Henry et al.   Science Translational Medicine

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis

(2014) Tomonori Kimura et al.   PLoS One

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Possible role of glial cells in the onset and progression of Lyme neuroborreliosis

(2009) Geeta Ramesh et al.   Journal of Neuroinflammation

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols