One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

(2021) John Jairo Aguilera-Correa et al.   Nanomaterials

Novel Structural hybrids of quinolone and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies

(2021) Sally I. Eissa et al.   BIOORGANIC CHEMISTRY

Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR

(2021) Mohammed M. S. Wassel et al.   BIOORGANIC CHEMISTRY

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

(2021) Ahmed Ragab et al.   Antibiotics-Basel

Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors

(2020) Mohamed A. Salem et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular docking study based on novel fused pyrazolothiazole scaffold

(2020) Hala F. Rizk et al.   Journal of the Iranian Chemical Society

Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies

(2020) Yousry A. Ammar et al.   BIOORGANIC CHEMISTRY

In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies

(2020) Eman A. Fayed et al.   BIOORGANIC CHEMISTRY

One-pot synthesis, crystal structure and antimicrobial activity of 6-benzyl-11-(p-tolyl)-6H-indolo[2,3-b]quinoline

(2020) Shaukat Ali et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity

(2020) Ashraf S. Hassan et al.   MOLECULES

Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives

(2020) Aya A.M. Mohammed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azoimine quinoline derivatives: Synthesis, classical and electrochemical evaluation of antioxidant, anti-inflammatory, antimicrobial activities and the DNA / BSA binding

(2020) Khaoula Douadi et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors

(2020) Mohammed M.S. Wassel et al.   JOURNAL OF MOLECULAR STRUCTURE

Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies

(2020) Srikanth Mamidala et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers

(2019) Ahmed M. Sh. El-Sharief et al.   BIOORGANIC CHEMISTRY

New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking

(2019) Ismail Althagafi et al.   MOLECULES

Fluoroquinolones structural and medicinal developments (2013–2018): Where are we now?

(2019) Ghadeer A.R.Y. Suaifan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking

(2019) Kanubhai D Katariya et al.   BIOORGANIC CHEMISTRY

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural, biological and in-silico study of quinoline-based chalcogensemicarbazones

(2019) Olivera R. Klisurić et al.   JOURNAL OF MOLECULAR STRUCTURE

Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors

(2019) Waad D. Alrohily et al.   MICROBIAL PATHOGENESIS

Derivatives of pyridine and thiazole hybrid: Synthesis, DFT, biological evaluation via antimicrobial and DNA cleavage activity

(2019) Serpil Eryılmaz et al.   BIOORGANIC CHEMISTRY

One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor

(2019) Mohamed A. Salem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro antioxidant activity of thiazolidinone derivatives of 1,3-thiazole and 1,3,4-thiadiazole

(2018) Mirjana Djukic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

4-Quinolone derivatives and their activities against Gram positive pathogens

(2018) Gui-Fu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids

(2018) Ruo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

(2018) Temístocles Italo de Santana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

(2018) Tuğba Kul Köprülü et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

4-Quinolone hybrids and their antibacterial activities

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes

(2017) Sabina Yasmin et al.   Scientific Reports

The emergence and evolution of antimicrobial resistance: Impact on a global scale

(2016) Andrew Y. Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Do we need new antibiotics?

(2016) J.-M. Rolain et al.   CLINICAL MICROBIOLOGY AND INFECTION

New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities

(2016) Yousry A. Ammar et al.   CURRENT ORGANIC SYNTHESIS

Synthesis and evaluation of isatin-β-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species

(2015) Xu-Meng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

(2015) Gregory S. Bisacchi   JOURNAL OF MEDICINAL CHEMISTRY

Catechol–rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR)

(2014) Catherine Zinglé et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rationale for Eliminating Staphylococcus Breakpoints for  -Lactam Agents Other Than Penicillin, Oxacillin or Cefoxitin, and Ceftaroline

(2014) J. Dien Bard et al.   CLINICAL INFECTIOUS DISEASES

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles

(2013) N.C. Desai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazolidinone–Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture

(2013) Christoph Nitsche et al.   JOURNAL OF MEDICINAL CHEMISTRY

SnCl2-Catalyzed Selective Atom Economic Imino Diels–Alder Reaction: Synthesis of 2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)quinolines

(2012) Rajendran Suresh et al.   JOURNAL OF ORGANIC CHEMISTRY

Kinetic and Chemical Mechanism of the Dihydrofolate Reductase fromMycobacterium tuberculosis

(2010) Clarissa M. Czekster et al.   BIOCHEMISTRY

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5

(2010) Mark R. Herbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness

(2009) Terry K. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Coumarin linked Naphthalimide Conjugates as Potential Anticancer and Antimicrobial Agents

(2009) Ahmed Kamal et al.   Letters in Drug Design & Discovery

Synthesis of substituted quinolines by the electrophilic cyclization of n-(2-alkynyl)anilines

(2009) Xiaoxia Zhang et al.   TETRAHEDRON