Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 6, Issue 3, Pages 201-209Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018009787847855
Keywords
Coumarin-thaizolyl; Naphthalimide; Anticancer; Antimicrobial; DNA binding affinity
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Funding
- DST, New Delhi
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A series of new coumarin linked naphthalimides (16a-g; 18a-g) was synthesised and evaluated for their in vitro anticancer activity against six cancer cell lines. Most of the compounds investigated have shown good to moderate anticancer activity against colon, breast and lung cancer cell lines. Thermal denaturation studies indicated that some compounds exhibited DNA binding ability. They were also found to be active against gram-positive and gram-negative bacterial strains as well as a few fungal strains.
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