Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies

Detecting SARS-CoV-2 3CLpro expression and activity using a polyclonal antiserum and a luciferase-based biosensor

(2021) Amornrat O'Brien et al.   VIROLOGY

SARS-CoV-2 variants and ending the COVID-19 pandemic

(2021) Arnaud Fontanet et al.   LANCET

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

(2021) Jingxin Qiao et al.   SCIENCE

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

(2021) Chamandi S. Dampalla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics

(2020) Arun K. Ghosh et al.   ChemMedChem

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design

(2020) Lewis D. Pennington et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

A human monoclonal antibody blocking SARS-CoV-2 infection

(2020) Chunyan Wang et al.   Nature Communications

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies

(2020) Atul Sharma et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors

(2020) Jun He et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

COVID-19: Drug Targets and Potential Treatments

(2020) Carmen Gil et al.   JOURNAL OF MEDICINAL CHEMISTRY

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

(2020) Athri D. Rathnayake et al.   Science Translational Medicine

Vaccines and Therapies in Development for SARS-CoV-2 Infections

(2020) David Wu et al.   Journal of Clinical Medicine

The SARS-CoV-2 main protease as drug target

(2020) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Advances in developing small molecule SARS 3CLpro inhibitors as potential remedy for corona virus infection

(2020) Manashjyoti Konwar et al.   TETRAHEDRON

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cerium(III) Chloride-Mediated Stereoselective Reduction of a 4-Substituted Cyclohexanone Using NaBH4

(2019) Prantik Maity et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

(2018) Anushka C. Galasiti Kankanamalage et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Deuterated drugs; updates and obviousness analysis

(2017) Graham S. Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

(2017) Niels C Pedersen et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry

(2017) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization

(2017) Lewis D. Pennington et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

(2016) Yunjeong Kim et al.   PLoS Pathogens

Reprint of “On the Size of the Active Site in Proteases. I. Papain”

(2012) Israel Schechter   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

(2012) Y. Kim et al.   JOURNAL OF VIROLOGY

Resolving Some Old Problems in Protein Crystallography

(2012) P. Evans   SCIENCE

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interleukin-1β expression by a recombinant porcine reproductive and respiratory syndrome virus

(2011) Steven R. Lawson et al.   VIRUS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine

(2009) Anna Vulpetti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY