Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection

(2016) Niels C. Pedersen et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors

(2015) Yasuhiro Shimamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses

(2015) Yunjeong Kim et al.   JOURNAL OF VIROLOGY

Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection

(2015) Niels C. Pedersen et al.   VETERINARY MICROBIOLOGY

Structures of theMiddle East respiratory syndrome coronavirus3C-like protease reveal insights into substrate specificity

(2015) Danielle Needle et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections

(2014) Ying-Ting Wang et al.   BMC Veterinary Research

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

(2014) X. Deng et al.   JOURNAL OF VIROLOGY

A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-Like Proteases of Emerging Coronaviruses

(2014) X. Deng et al.   JOURNAL OF VIROLOGY

The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis

(2014) Niels C. Pedersen et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

An update on feline infectious peritonitis: Virology and immunopathogenesis

(2014) Niels C. Pedersen   VETERINARY JOURNAL

An update on feline infectious peritonitis: Diagnostics and therapeutics

(2014) Niels C. Pedersen   VETERINARY JOURNAL

Antiviral drugs specific for coronaviruses in preclinical development

(2014) Adeyemi O Adedeji et al.   Current Opinion in Virology

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

(2013) Allan M. Prior et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-SARS coronavirus agents: a patent review (2008 – present)

(2013) Vathan Kumar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Phylogenetic Analysis of Feline Coronavirus Strains in an Epizootic Outbreak of Feline Infectious Peritonitis

(2013) E.N. Barker et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease

(2012) Yunjeong Kim et al.   ANTIVIRAL RESEARCH

Intranasal Treatment with Poly(I{middle dot}C) Protects Aged Mice from Lethal Respiratory Virus Infections

(2012) J. Zhao et al.   JOURNAL OF VIROLOGY

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

(2012) Y. Kim et al.   JOURNAL OF VIROLOGY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Feline infectious peritonitis: Role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats

(2012) Niels C. Pedersen et al.   VIRUS RESEARCH

Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

(2011) Y. Fischer et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay

(2011) Kyeong-Ok Chang et al.   VIROLOGY

Individual and common inhibitors of coronavirus and picornavirus main proteases

(2009) Chih-Jung Kuo et al.   FEBS LETTERS

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

(2009) Cheng-Chung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A review of feline infectious peritonitis virus infection: 1963–2008

(2009) Niels C. Pedersen   JOURNAL OF FELINE MEDICINE AND SURGERY

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

(2009) Craig W. Day et al.   VIROLOGY

Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis

(2009) Niels Pedersen et al.   Viruses-Basel

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

(2008) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols