Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK

Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors

(2021) Li Ding et al.   MEDICINAL RESEARCH REVIEWS

Avoiding Drug Resistance in HIV Reverse Transcriptase

(2021) Maria E. Cilento et al.   CHEMICAL REVIEWS

Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring

(2021) Li Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles

(2021) Zhao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs

(2021) Li Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy

(2021) Jing Zhu et al.   Acta Pharmaceutica Sinica B

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

(2020) Dongwei Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

(2020) Dongwei Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

(2020) Ting-Ting Li et al.   MOLECULES

Radiosensitization of human pancreatic cancer by piperlongumine analogues

(2020) Hao Ma et al.   CHINESE CHEMICAL LETTERS

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors

(2020) Xiaomei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

(2019) Hui Wang et al.   ACS Chemical Neuroscience

Fifty Years in Search of Selective Antiviral Drugs

(2019) Erik De Clercq   JOURNAL OF MEDICINAL CHEMISTRY

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains

(2019) Yali Sang et al.   BIOORGANIC CHEMISTRY

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

(2019) Sheng Han et al.   CHINESE CHEMICAL LETTERS

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors

(2019) Yali Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

(2019) Kaijun Jin et al.   Acta Pharmaceutica Sinica B

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): Our past twenty years

(2019) Chunlin Zhuang et al.   Acta Pharmaceutica Sinica B

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors

(2019) Sheng Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles

(2019) Yali Sang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1

(2018) KaiJun Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Doravirine

(2018) Marie-Alice Colombier et al.   Current Opinion in HIV and AIDS

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors

(2018) Shuang-Xi Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search

(2014) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rotamers or Diastereomers? An Overlooked NMR Solution

(2012) Dennis X. Hu et al.   JOURNAL OF ORGANIC CHEMISTRY

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols