Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell–like Differentiation in Patients with Granulomatosis with Polyangiitis

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits

(2020) Jinyong Choi et al.   NATURE IMMUNOLOGY

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation

(2019) Bin Hu et al.   AGING CELL

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells

(2019) Amber Papillion et al.   Science Immunology

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis

(2018) Daigo Nakazawa et al.   Nature Reviews Rheumatology

Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells

(2018) Peng Li et al.   Frontiers in Immunology

Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis

(2017) Anja Kerstein et al.   JOURNAL OF AUTOIMMUNITY

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?

(2017) Shane Crotty   Cold Spring Harbor Perspectives in Biology

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

(2017) Subhash K. Tripathi et al.   Cell Reports

The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus

(2016) Aleš Goropevšek et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Human Circulating T Follicular Helper Cell Subsets in Health and Disease

(2016) Hideki Ueno   JOURNAL OF CLINICAL IMMUNOLOGY

Corrigendum: Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

IL-7 signalling represses Bcl-6 and the TFH gene program

(2016) Paul W. McDonald et al.   Nature Communications

Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans

(2016) Nathalie Schmitt et al.   Cell Reports

Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation

(2016) Xindong Liu et al.   Cell Reports

Regulators of Tfh Cell Differentiation

(2016) Gajendra M. Jogdand et al.   Frontiers in Immunology

Predominance of PR3 specific immune response and skewed TH17 vs. T-regulatory milieu in active granulomatosis with polyangiitis

(2015) Lekha Rani et al.   CYTOKINE

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Abnormal Expression Pattern of the IL-2 Receptorβ-Chain on CD4+T Cells in ANCA-Associated Vasculitis

(2014) Benjamin Wilde et al.   DISEASE MARKERS

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

A negative feedback loop mediated by the Bcl6–cullin 3 complex limits Tfh cell differentiation

(2014) Rebecca Mathew et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signal tranducers and activators of transcription: Expression and function in anti-neutrophil cytoplasmic antibody-associated vasculitis

(2014) BENJAMIN WILDE et al.   Molecular Medicine Reports

Identification of STAT5A and STAT5B Target Genes in Human T Cells

(2014) Takahiro Kanai et al.   PLoS One

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Have Defective Treg Cell Function Exacerbated by the Presence of a Suppression-Resistant Effector Cell Population

(2013) Meghan E. Free et al.   ARTHRITIS AND RHEUMATISM

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Helper T-cell identity and evolution of differential transcriptomes and epigenomes

(2013) Golnaz Vahedi et al.   IMMUNOLOGICAL REVIEWS

STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6

(2013) S. R. Walker et al.   MOLECULAR AND CELLULAR BIOLOGY

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

(2013) Xuexian O Yang et al.   NATURE IMMUNOLOGY

Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis

(2013) Y. Zhao et al.   RHEUMATOLOGY

Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA)

(2013) Wayel H Abdulahad et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function

(2012) Roza I. Nurieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

(2012) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Multidimensional Single Cell Based STAT Phosphorylation Profiling Identifies a Novel Biosignature for Evaluation of Systemic Lupus Erythematosus Activity

(2011) Xinfang Huang et al.   PLoS One

Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis

(2010) Chris Cheadle et al.   ARTHRITIS AND RHEUMATISM

Predominance of IgGl and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders

(2010) E. BROUWER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

(2009) Nathalie Schmitt et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission

(2008) Wayel H. Abdulahad et al.   ARTHRITIS AND RHEUMATISM