Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

(2011) Kenneth J. Oestreich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

(2011) Christian Hurtz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-bet in disease

(2011) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

(2010) Matthias Merkenschlager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

(2010) Sara A. Miller et al.   MOLECULAR CELL

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

(2010) Anna-Barbara Stittrich et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

(2010) Shane Crotty et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Regulation and Functions of Blimp-1 in T and B Lymphocytes

(2008) Gislâine Martins et al.   Annual Review of Immunology

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

(2008) S. A. Miller et al.   GENES & DEVELOPMENT

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY