Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Adaptive immunity to SARS-CoV-2 and COVID-19

(2021) Alessandro Sette et al.   CELL

Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

(2021) Anthony T. Tan et al.   Cell Reports

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

(2021) Merryn Voysey et al.   LANCET

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

(2021) Dami A. Collier et al.   NATURE

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

(2021) Fatima Amanat et al.   mBio

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

(2021) Sandile Cele et al.   NATURE

Structural basis for broad coronavirus neutralization

(2021) Maximilian M. Sauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

(2021) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

(2020) Ling Ni et al.   IMMUNITY

Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data

(2020) Birkir Reynisson et al.   JOURNAL OF PROTEOME RESEARCH

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

(2020) Benjamin J. Meckiff et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice

(2020) Yushi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

(2020) Alina S. Shomuradova et al.   IMMUNITY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals

(2020) Jian Zhang et al.   Nature Microbiology

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

(2019) Danika L. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools

(2019) Faviel F Gonzalez-Galarza et al.   NUCLEIC ACIDS RESEARCH

The Immune Epitope Database (IEDB): 2018 update

(2018) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

(2017) Antje Heit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

(2017) Koji Atarashi et al.   SCIENCE

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Clustered MicroRNAs of the Epstein-Barr Virus Cooperatively Downregulate an Epithelial Cell-Specific Metastasis Suppressor

(2014) Teru Kanda et al.   JOURNAL OF VIROLOGY

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Transcriptional regulation of follicular T-helper (Tfh) cells

(2013) Xindong Liu et al.   IMMUNOLOGICAL REVIEWS

Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules

(2013) Yan Jiang et al.   INTERNATIONAL IMMUNOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY