Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis

(2021) Jian‐Yu Yang et al.   Molecular Oncology

Knockdown of SF3B1 inhibits cell proliferation, invasion and migration triggering apoptosis in breast cancer via aberrant splicing

(2020) Ling Zhang et al.   Breast Cancer

Tximeta: Reference sequence checksums for provenance identification in RNA-seq

(2020) Michael I. Love et al.   PLoS Computational Biology

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

(2020) Aaron J. Grossberg et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

(2020) Luisa F. Escobar-Hoyos et al.   CANCER CELL

Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation

(2020) Pooja Popli et al.   Cell Death & Disease

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

(2020) Sandra Valle et al.   Nature Communications

The biological function and clinical significance of SF3B1 mutations in cancer

(2020) Zhixia Zhou et al.   Biomarker Research

Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma

(2020) Juan L. López-Cánovas et al.   CANCER LETTERS

Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

(2019) Fabio Giuseppe Liberante et al.   Scientific Reports

Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types

(2019) Mercedes del Rio-Moreno et al.   Translational Research

Dysregulation of the splicing machinery is associated to the development of non-alcoholic fatty liver disease

(2019) Mercedes del Río-Moreno et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

Spliceosome Component SF3B1 as Novel Prognostic Biomarker and Therapeutic Target for Prostate Cancer

(2019) Juan M. Jiménez-Vacas et al.   Translational Research

Genome-Wide Profiling Reveals the Landscape of Prognostic Alternative Splicing Signatures in Pancreatic Ductal Adenocarcinoma

(2019) Chengkun Yang et al.   Frontiers in Oncology

Survival-Associated Alternative Messenger RNA Splicing Signatures in Pancreatic Ductal Adenocarcinoma: A Study Based on RNA-Sequencing Data

(2019) Yu-Jie Zhou et al.   DNA AND CELL BIOLOGY

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

(2019) Megan Stevens et al.   Frontiers in Genetics

A somatostatin receptor subtype-3 (SST3) peptide agonist shows antitumor effects in experimental models of Nonfunctioning Pituitary Tumors

(2019) Mari Carmen Vázquez-Borrego et al.   CLINICAL CANCER RESEARCH

Altered RNA Processing in Cancer Pathogenesis and Therapy

(2019) Esther A. Obeng et al.   Cancer Discovery

CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

(2019) Xènia Serrat et al.   PLoS Genetics

The role of JNK in prostate cancer progression and therapeutic strategies

(2019) Ruiyuan Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

(2018) Pablo Cabezas-Sainz et al.   BMC CANCER

Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

Pancreatic cancer stem cells: A state or an entity?

(2018) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

(2017) Jessica Brandi et al.   Journal of Proteomics

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

(2017) Brenton R Paolella et al.   eLife

Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice

(2016) Pouria Jandaghi et al.   GASTROENTEROLOGY

RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4

(2016) Marie K. Kirby et al.   Molecular Oncology

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

KRAS-related proteins in pancreatic cancer

(2016) Karen M. Mann et al.   PHARMACOLOGY & THERAPEUTICS

Modulating splicing with small molecular inhibitors of the spliceosome

(2016) Kerstin A. Effenberger et al.   Wiley Interdisciplinary Reviews-RNA

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Pancreatic Cancer Stem-like Cells Display Aggressive Behavior Mediated via Activation of FoxQ1

(2014) Bin Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

(2014) Irene Miranda-Lorenzo et al.   NATURE METHODS

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression

(2012) H Bernard et al.   ONCOGENE

Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer

(2010) C. E. Edling et al.   CLINICAL CANCER RESEARCH

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Characterization of Alternative Spliceoforms and the RNA Splicing Machinery in Pancreatic Cancer

(2010) Patricia E. Carrigan et al.   PANCREAS

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling

(2008) Lynda Elghazi et al.   GASTROENTEROLOGY