Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Jia, Mohit Kumar Jolly, Herbert Levine
Summary: The epithelial-mesenchymal transition (EMT) is a crucial cellular process for wound healing, cancer metastasis, and embryonic development. Recent studies have shown that hybrid epithelial/mesenchymal states, possessing both epithelial and mesenchymal traits, play a significant role in cancer metastasis and resistance to therapies. NRF2 has been identified as a stabilizing factor for these hybrid states. This research incorporates a phenomenological epigenetic feedback effect into a computational model for EMT signaling and demonstrates its stabilizing effect on the hybrid state if NRF2 influences SNAIL at an epigenetic level.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Prakruthi Manjunatha, Shaurya Goyal, Vignesh A. Kasiviswanathan, Yeshwanth Mahesh, Soundharya Ramu, Isabelle McMullen, Jason A. A. Somarelli, Mohit Kumar Jolly
Summary: ELF3 is a factor strongly associated with an epithelial phenotype and is inhibited during EMT. It inhibits the progression of EMT and can counteract EMT induction even in the presence of EMT-inducing factors. The prognostic capacity of ELF3 is specific to cell-of-origin or lineage.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Bo Yi, KeJu Dai, ZhiQiang Yan, ZhaoHui Yin
Summary: This study aimed to investigate the biological functions of circPLCE1 on epithelial mesenchymal transformation (EMT), glycolysis, and tumor-associated macrophage (TAM) polarization in colorectal cancer (CRC). The results showed that circPLCE1 expression was increased, while miR-485-5p expression was decreased in CRC. Knockdown of circPLCE1 inhibited CRC proliferation, glycolysis, and M2 macrophage polarization, while decreased miR-485-5p accelerated EMT, glycolysis, and TAM M2 polarization in CRC. Mechanism studies revealed that circPLCE1 acted as a competitive endogenous RNA to mediate ACTG1 expression through binding with miR-485-5p. In summary, circPLCE1 promotes EMT, glycolysis, and TAM M2 polarization through regulating the miR-485-5p/ACTG1 axis in CRC.
Article
Medicine, Research & Experimental
Yu Zeng, Tianshi Que, Jie Lin, Zhengming Zhan, Anqi Xu, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Hao Long, Xian Zhang, Ye Song
Summary: This study identified an oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin that promotes migration and invasion in glioma, leading to an unfavorable prognosis. HMGA1 and vimentin were associated with specific subtypes of glioma.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Oncology
Jiansong Wang, Jianjun Luo, Xuecheng Wu, Zhiyong Gao
Summary: Recent research found that circ_0000629 promotes CDC73 expression by competitively binding to miR-1290, thereby inhibiting the growth and metastasis of bladder cancer cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding, Jianghua Zheng
Summary: The study found that circDPP4 was overexpressed in PCa tissues and cell lines, and its expression was associated with Gleason score and clinical stage of PCa patients. In vitro experiments showed that circDPP4 knockdown inhibited PCa cell proliferation, migration, invasion, and cell cycle progression, while circDPP4 overexpression promoted these processes. Knockdown of circDPP4 also suppressed PCa tumor growth in vivo, indicating its potential as a therapeutic target for PCa.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Review
Biochemistry & Molecular Biology
Melodie Migault, Sunil Sapkota, Cameron P. Bracken
Summary: This review discusses the large number of regulators involved in epithelial-mesenchymal transition (EMT) and the implications for understanding EMT and the genetic machinery controlling complex biological processes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Manxiu Huai, Junxiang Zeng, Wensong Ge
Summary: The study found that artemisinin can ameliorate intestinal inflammation by promoting macrophage polarization to M2 phenotype and inhibiting the process of EMT. This suggests that artemisinin may be applied to the rehabilitation of IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoti Lin, Weiyu Chen, Fengqin Wei, Xiaoming Xie
Summary: By targeting the regulation of circRGPD6 on metastatic breast cancer stem cells, a new therapeutic approach has been developed to inhibit the expression of stem cell markers and increase the expression of DNA damage markers. TV-circRGPD6 significantly suppresses the metastasis of breast cancer stem cells and works synergistically with docetaxel to provide significant therapeutic responses for metastatic breast cancer.
Article
Engineering, Biomedical
Elise C. Wilcox, Elazer R. Edelman
Summary: Culturing endothelial cells on different substrates influences their phenotypes and functions, with 3D culture inducing HIF1-a expression in response to hypoxia gradients, while 2D culture undergoes endothelial-to-mesenchymal transition. Endothelial cells have unique responses compared to epithelial cells and fibroblasts, emphasizing the importance of considering their microenvironment in culture conditions.