Review
Biochemistry & Molecular Biology
Hyeji Jeon, Su Min Seo, Tae Wan Kim, Jaesung Ryu, Hyejeong Kong, Si Hyeong Jang, Yong Soo Jang, Kwang Seock Kim, Jae Hoon Kim, Seongho Ryu, Seob Jeon
Summary: The aim of this study was to develop a new diagnostic biomarker for identifying specific serum exosomal miRNAs in epithelial ovarian cancer (EOC) and investigate the target gene of the miRNA to understand the molecular mechanisms involved. The results showed that miRNA-1290 was significantly overexpressed in serum exosomes and tissues of EOC patients compared to those with benign ovarian neoplasms. Furthermore, the study suggested that serum exosomal miR-1290 could be considered as a potential biomarker for differentiating EOC from benign ovarian neoplasms, and SOCS4 might be a potential target gene of miR-1290 in EOC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lei Sun, Arabella Wan, Zhuolong Zhou, Dongshi Chen, Heng Liang, Chuwei Liu, Shijia Yan, Yi Niu, Ziyou Lin, Siyue Zhan, Shanfeng Wang, Xianzhang Bu, Weiling He, Xiongbin Lu, Anlong Xu, Guohui Wan
Summary: The study identified an RNA-binding protein RALY as a critical regulator in colorectal cancer metabolism, promoting the post-transcriptional processing of miRNAs that downregulate metabolism-associated genes and reprogram mitochondrial metabolism in cancer cells. Increased levels of RALY were associated with poor prognosis in CRC patients expressing low levels of mitochondrion-associated genes, and this effect was facilitated by N6-methyladenosine switch under reactive oxygen species stress. Inhibition of m6A methylation abolished RALY recognition of pri-miRNAs, leading to inhibition of colorectal tumor growth and progression both in vivo and in organoid models.
Review
Chemistry, Medicinal
Abolfazl Shakeri, Mohsen Gahnbari, Aida Tasbandi, Amirhossein Sahebkar
Summary: Natural products are a focus of research due to their pharmacological applications, chemical diversity, and low side effects, with some compounds showing anticancer activity and serving as sources for current anticancer drugs. The anticarcinogenic effects of natural products are partly mediated through microRNA-21 expression modulation.
PHYTOTHERAPY RESEARCH
(2021)
Review
Oncology
Valentina Doldi, Rihan El Bezawy, Nadia Zaffaroni
Summary: Prostate cancer is a common and deadly tumor in men, with high heterogeneity making individual patient management challenging. microRNAs are crucial in determining prostate cancer response to radiation and drug therapy, potentially serving as novel therapeutic targets or tools for improving treatment response.
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Woo Ryung Kim, Eun Gyung Park, Du Hyeong Lee, Yun Ju Lee, Woo Hyeon Bae, Heui-Soo Kim
Summary: Circular RNAs (circRNAs) are endogenous RNAs that regulate gene expression at different levels and have been identified as novel diagnostic biomarkers and potential therapeutic targets for various cancer types. They interact with microRNAs (miRNAs), which play crucial roles in cancer as regulatory elements. Some miRNAs are derived from transposable elements (MDTEs) and can relocate within the genome. The genetic interactions between miRNAs and circRNAs form complex regulatory networks involved in tumorigenesis and cancer progression. This review emphasizes the biological regulation of circRNAs, miRNAs, and their target genes in different cancers, and highlights the biological importance of MDTEs interacting with oncogenic or tumor-suppressive circRNAs in tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aurora Eliana Merulla, Michele Stella, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Cinzia Di Pietro, Michele Purrello, Davide Barbagallo
Summary: This study investigates the role of circSMARCA5 in controlling miRNAs 126-3p and 515-5p in GBM cells, revealing a new subnetwork regulated by circSMARCA5 which affects downstream mRNA targets IGFBP2 and NRAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tingting Fu, Yifei Lin, Ling Lin, Yong Yang, Qiong Guo, Youlin Long, He He, Yige Bao, Tianhai Lin, Junru Chen, Zhenglong Chen, Liang Du, Ga Liao, Banghua Liao, Jin Huang
Summary: This study aimed to explore the role of non-coding RNA in upper tract urothelial carcinoma (UTUC) and provide precise references for non-coding RNA in the management of UTUC patients. The results suggest that miRNAs and other non-coding RNAs may be involved in the pathogenesis of UTUC and potential biomarkers have been identified. These findings have important implications for personalized and targeted therapies.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Review
Medicine, Research & Experimental
Bin Zhang, Liming Yang, Yang He, Dali Han, Peng Qi, Panfeng Shang
Summary: Bladder cancer is the most common urothelial cancer, and metabolic reprogramming is gaining attention in its development. Recent studies have shown a strong correlation between noncoding RNAs and metabolic reprogramming in bladder cancer. Noncoding RNAs can directly or indirectly regulate the expression and function of metabolic enzymes in bladder cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Cell Biology
Wei Liu, Yuanyuan Xiong, Renhua Wan, Renfeng Shan, Jianfeng Li, Wu Wen
Summary: Circular RNAs (circRNAs) are a newly discovered group of covalently-closed circular non-coding RNAs, which have been found to play either oncogenic or tumor-suppressor roles depending on the cellular context. One specific circRNA, circMTO1, originating from exons of MTO1, has been shown to be abnormally expressed in various malignant tumors, contributing to tumor initiation and progression. Further research is needed to fully understand the roles of circMTO1 in cancer and its potential as a therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yi Li, Lihui Sun, Xiangyang Guo, Na Mo, Jinku Zhang, Chong Li
Summary: Most etiology studies of bladder cancer focus on genetic changes, surgery is the main treatment but chemotherapy is needed due to high recurrence rates, and there are differences in chemosensitivity among patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Dean Rao, Chengpeng Yu, Jiaqi Sheng, Enjun Lv, Wenjie Huang
Summary: Circular RNAs (circRNAs) are a class of stable and resistant non-coding RNAs widely expressed in eukaryotic cells, playing important roles in various diseases. CircRNA Foxhead box O3 (circFOXO3) has been studied extensively in cancers as a molecular sponge. Understanding the roles of circFOXO3 can enrich our knowledge of circRNA functions in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lais Reis-das-Merces, Tatiana Vinasco-Sandoval, Rafael Pompeu, Aline Cruz Ramos, Ana K. M. Anaissi, Samia Demachki, Paulo Pimentel de Assumpcao, Amanda F. Vidal, Andrea Ribeiro-dos-Santos, Leandro Magalhaes
Summary: This study investigates the expression profiles of circular RNAs (circRNAs) and their potential as minimally invasive biomarkers for gastric cancer (GC). Results show that certain circRNAs have consistent expression profiles across different methods and types of samples, and functional enrichment analysis reveals important signaling pathways related to GC. These findings suggest that circRNAs could serve as promising biomarkers for the diagnosis and clinical management of GC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
YingYing Zhuang, LiYa Li, HaiNing Wu, TaiYong Fang
Summary: This study found that circACVR2A is significantly upregulated in gastric cancer tissues, and its downregulation can promote cell proliferation and metastasis while suppressing the expression of E-cadherin and Vimentin. The miR-1290 inhibitor can reverse the effect of circACVR2A on cell progression. Further research indicates that circACVR2A functions as a tumor suppressor oncogene by competitively binding to miR-1290.
JOURNAL OF ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Manu Shivakumar, Seonggyun Han, Younghee Lee, Dokyoon Kim
Summary: This study provides a higher resolution of molecular insight into the crosstalk between two epigenetic factors, DNA methylation and miRNA. Results showed that these interactions are important in cancer, and it is timely to identify and understand the underlying mechanisms based on epigenetic markers and their interactions in cancer, leading to alternative splicing with primary functional impact.