Article
Microbiology
Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang
Summary: Current strategies for treating drug-resistant tuberculosis are limited in effectiveness and have undesirable side effects. Therefore, research on new treatments, including innovative medications, is required. Host-directed therapy (HDT) has emerged as a viable strategy for enhancing protective immunity against infections. In this study, baicalein, derived from Scutellariae radix, was found to inhibit pyroptosis in Mycobacterium tuberculosis-infected macrophages and promote autophagy, suggesting its potential as a new adjunctive HDT drug.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Xueyi Nie, Boli Ma, Xiaotan Yuan, Mengyuan Li, Yueyang Liu, Yuxin Hou, Yi Yang, Jinrui Xu, Yujiong Wang
Summary: This article aims to explore the regulation of the NLRP3 inflammasome and pyroptosis by endoplasmic reticulum stress (ERS) in THP-1 macrophages infected with Mycobacterium bovis Bacillus Calmette-Guérin (BCG). The results showed that BCG infection induced ERS, NLRP3 inflammasome activation and pyroptosis in THP-1 macrophages, which was inhibited by the ERS inhibitor TUDCA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jiexia Wen, Yumei Chang, Shanshan Huo, Wenyan Li, Heling Huang, Yunhuan Gao, Hongyu Lin, Jianlou Zhang, Yonghong Zhang, Yuzhu Zuo, Xuebin Cao, Fei Zhong
Summary: Tanshinone IIA has a strong anti-atherogenic function by inhibiting the activation of NLRP3 inflammasome, which plays a vital role in atherogenesis. The mechanism involves inhibiting NF-kappa B activation, downregulating pro-IL-1 beta and NLRP3 expression, and reducing oxLDL-induced cellular damage to prevent NLRP3 inflammasome assembly.
Article
Chemistry, Medicinal
Shun Wu, Dingchun Lu, Babu Gajendran, Qilan Hu, Jian Zhang, Shengquan Wang, Minzhen Han, Yini Xu, Xiangchun Shen
Summary: Diabetic cardiomyopathy (DCM) is a common complication in diabetic patients leading to heart failure, primarily caused by endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism. Tanshinone II A (Tan IIA), the main active component of a Chinese medicine called Salviae miltiorrhizae radix et rhizome, has been found to have protective effects against cardiovascular disease and diabetes. This study aimed to investigate whether Tan IIA alleviates ERS-mediated DCM via SIRT1, and the results showed that Tan IIA improved the pathological changes in diabetic mice hearts and inhibited ERS-related protein and mRNA expression.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma, Shibin Cheng
Summary: The understanding of sterile inflammation and its effects on pregnancy complications such as preeclampsia is still in its early stages. Emerging evidence suggests that sterile inflammation regulated by pathways such as the inflammasome-gasdermins-caspase-1 axis may contribute to the development of preeclampsia. Further research is needed to elucidate the mechanisms underlying these inflammatory pathways and potential therapeutic strategies for treating these complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-xue Wang, Chao Ren, Ren-qi Yao, Yi-nan Luo, Yue Yin, Yao Wu, Ning Dong, Xiao-mei Zhu, Yong-ming Yao
Summary: SESN2 plays a crucial role in sepsis by inhibiting NLRP3 inflammasome hyperactivation, reducing CASP-1-dependent pyroptosis, and improving sepsis outcomes. Lack of SESN2 leads to increased inflammatory response and higher mortality.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Omar Escobar-Chavarria, Alejandro Benitez-Guzman, Itzel Jimenez-Vazquez, Jacobo Carrisoza-Urbina, Lourdes Arriaga-Pizano, Sara Huerta-Yepez, Guillermina Baay-Guzman, Jose A. Gutierrez-Pabello
Summary: The necrotic cell death induced by Mycobacterium bovis and the inflammasome activation in bovine macrophages help control bacterial growth.
Article
Environmental Sciences
Yuanyuan Zhou, Hanyu Liao, Shanshan Yin, Pengqiao Wang, Xiaoqing Ye, Jianyun Zhang
Summary: Organophosphate esters (OPEs) are widely used man-made chemicals detected in various human-related samples. This study evaluated the toxicity and mechanisms of nine commonly detected OPEs on human hepatocellular carcinomas. The OPEs induced apoptosis, oxidative stress, endoplasmic reticulum stress, and NLRP3 inflammasome activation. Different types of OPEs showed varying effects on ROS overproduction, DNA damage, and cytotoxicity.
ENVIRONMENTAL POLLUTION
(2023)
Review
Immunology
Yunlong Liu, Yan Sun, Juening Kang, Ziqi He, Quan Liu, Jihua Wu, Derong Li, Xiang Wang, Zhiwei Tao, Xiaofeng Guan, Wusheng She, Hua Xu, Yaoliang Deng
Summary: The pathogenesis of calcium oxalate nephrolithiasis is mainly related to inflammatory injury caused by the cell-crystal reaction. Inflammatory response triggers a series of injury reactions and release of inflammatory factors, promoting the formation and development of crystals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Can Wan, Xiao-Qi Liu, Mei Chen, Hui-Han Ma, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang
Summary: The study found that tanshinone IIA can promote the transportation of A beta by alleviating SIRT1-mediated ER stress in BMECs, improving cognitive deficits in APP/PS1 mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Shuangyu Lv, Xiaotian Li, Honggang Wang
Summary: The impact of endoplasmic reticulum stress on NLRP3 inflammasome in diabetes and its associated mechanism have not been fully understood, and further research in this area will provide valuable insights for future basic research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shun Xu, Menghan Wang, Yu Chen, Zaoli Shen, Qing Jia, Aili Wang
Summary: Danshen-derived tanshinone IIA can reduce cardiomyocyte pyroptosis by inhibiting the expression of NLRP3 inflammasome, thus exerting cardioprotective effects.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Cell Biology
Hang Zhang, Zheyi Jiang, Chuanbin Shen, Han Zou, Zhiping Zhang, Kaitao Wang, Renren Bai, Yanhua Kang, Xiang-Yang Ye, Tian Xie
Summary: The study found that 5-HMF has a protective effect against endotoxin-induced acute lung injury (ALI) by reducing lung damage, neutrophil infiltration, and inflammatory cytokine release. The mechanism involves inhibiting the NF-kappa B signaling pathway, NLRP3 inflammasome activation, and endoplasmic reticulum (ER) stress to combat NLRP3 inflammasome-related inflammatory disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mengyuan Li, Yueyang Liu, Xueyi Nie, Boli Ma, Yabo Ma, Yuxin Hou, Yi Yang, Jinrui Xu, Yujiong Wang
Summary: The study found that S100A4 and GSDMD were significantly up-regulated in the peripheral blood of patients with pulmonary tuberculosis, and S100A4 promotes macrophage pyroptosis induced by Mycobacterium tuberculosis infection through activation of the NF-κB/NLRP3 inflammasome signaling pathway. These findings provide new insights into the role of S100A4 in Mycobacterium tuberculosis-induced macrophage pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Wai Chin Chong, Madhur D. Shastri, Gregory M. Peterson, Rahul P. Patel, Prabuddha S. Pathinayake, Kamal Dua, Nicole G. Hansbro, Alan C. Hsu, Peter A. Wark, Shakti Dhar Shukla, Matt D. Johansen, Kate Schroder, Philip M. Hansbro
Summary: Inflammation is a complex immune response essential for protection and tissue healing, but dysregulation can lead to inflammatory diseases. Endoplasmic reticulum stress and inflammasomes play crucial roles in activating inflammatory pathways, with the former potentially exacerbating the latter, suggesting new therapeutic targets for inflammatory disorders.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)