Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice

Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host

(2021) George Hajishengallis et al.   PERIODONTOLOGY 2000

Oral Treponema denticola Infection Induces Aβ1–40 and Aβ1–42 Accumulation in the Hippocampus of C57BL/6 Mice

(2021) Xinyi Su et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Multi-Replicated Enrichment Communities as a Model System in Microbial Ecology

(2021) Sylvie Estrela et al.   Frontiers in Microbiology

A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology

(2021) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms underlying the association between periodontitis and atherosclerotic disease

(2020) Harvey A. Schenkein et al.   PERIODONTOLOGY 2000

Effects of Porphyromonas gingivalis and Its Underlying Mechanisms on Alzheimer-Like Tau Hyperphosphorylation in Sprague-Dawley Rats

(2020) Zhiqun Tang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Association between periodontitis and cognitive impairment: Analysis of national health and nutrition examination survey (NHANES) III

(2019) Cheng‐En Sung et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis

(2019) Hong Min Ng et al.   Frontiers in Cellular and Infection Microbiology

Detection of Treponema denticola in Chronic Periodontitis by Quantitative Real-Time Polymerase Chain Reaction

(2019) Xiongjun Xu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Helicobacter pylori Filtrate Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Glycogen Synthase Kinase-3β

(2018) Xiu-Lian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease

(2018) Richard Hodson   NATURE

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

(2018) Vladimir Ilievski et al.   PLoS One

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Periodontal disease associates with higher brain amyloid load in normal elderly

(2015) Angela R. Kamer et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE−/−Mice Causally Links Periodontal Disease and Atherosclerosis

(2014) Sasanka S. Chukkapalli et al.   INFECTION AND IMMUNITY

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

(2011) Michael Sy et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Virulence Factors of the Oral Spirochete Treponema denticola

(2010) S.G. Dashper et al.   JOURNAL OF DENTAL RESEARCH

Periodontitis: a polymicrobial disruption of host homeostasis

(2010) Richard P. Darveau   NATURE REVIEWS MICROBIOLOGY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON