Notoginsenoside R1 attenuates oxidative stress‐induced osteoblast dysfunction through JNK signalling pathway

Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review)

(2021) Andrei Bondar et al.   Experimental and Therapeutic Medicine

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

(2020) Hai Liu et al.   Drug Design Development and Therapy

Notoginsenoside R1 Suppresses Inflammatory Signaling and Rescue Renal Ischemia-reperfusion Injury in Experimental Rats

(2020) Chuming Fan et al.   MEDICAL SCIENCE MONITOR

Current Data Regarding the Relationship between Type 2 Diabetes Mellitus and Cardiovascular Risk Factors

(2020) Cosmin Mihai Vesa et al.   Diagnostics

Curcumin Protects Osteoblasts From Oxidative Stress-Induced Dysfunction via GSK3β-Nrf2 Signaling Pathway

(2020) Xumin Li et al.   Frontiers in Bioengineering and Biotechnology

Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity

(2020) Yeong Lan Tan et al.   Cells

Notoginsenoside R1 alleviates oxidized low-density lipoprotein-induced apoptosis, inflammatory response, and oxidative stress in HUVECS through modulation of XIST/miR-221-3p/TRAF6 axis

(2020) Jian Zhao et al.   CELLULAR SIGNALLING

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression

(2019) Bin Zhang et al.   MOLECULES

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy

(2019) Ping Zhou et al.   Cells

The epidemiology of osteoporosis, associated fragility fractures, and management gap in China

(2019) Fan Yu et al.   Archives of Osteoporosis

Notoginsenoside R1 up-regulates microRNA-132 to protect human lung fibroblast MRC-5 cells from lipopolysaccharide-caused injury

(2019) Shan Cong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Notoginsenoside R1 alleviates lipopolysaccharide-triggered PC-12 inflammatory damage via elevating microRNA-132

(2019) Yuanliang Sun et al.   Artificial Cells Nanomedicine and Biotechnology

Notoginsenoside R1 protects WI‐38 cells against lipopolysaccharide‐triggered injury via adjusting the miR‐181a/TLR4 axis

(2019) Daolin Qian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

AKT-GSK3β Signaling Pathway Regulates Mitochondrial Dysfunction-Associated OPA1 Cleavage Contributing to Osteoblast Apoptosis: Preventative Effects of Hydroxytyrosol

(2019) W. J. Cai et al.   Oxidative Medicine and Cellular Longevity

Applications of Antioxidants in Metabolic Disorders and Degenerative Diseases: Mechanistic Approach

(2019) Mohamed M. Abdel-Daim et al.   Oxidative Medicine and Cellular Longevity

ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells

(2019) Pingping Sun et al.   NEUROTOXICOLOGY AND TERATOLOGY

Anti-osteoporosis effects of osteoking via reducing reactive oxygen species

(2019) Di Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synergistic antioxidant effects of resveratrol and curcumin against fipronil-triggered oxidative damage in male albino rats

(2019) Gadah AlBasher et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury

(2018) Liu Tu et al.   NEUROCHEMICAL RESEARCH

RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products

(2018) Y. X. Mao et al.   Cell Death & Disease

Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation

(2018) Xiaoliang Jiang et al.   Redox Biology

Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation

(2018) Brianna H. Shares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration

(2018) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ERK and JNK pathways in the regulation of metabolic reprogramming

(2018) Salvatore Papa et al.   ONCOGENE

Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria

(2018) Diego Grassi et al.   NEUROBIOLOGY OF DISEASE

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

(2016) Gerg| A. Molnár et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

(2016) Qiaozhen Zhou et al.   DISEASE MARKERS

Notoginsenoside R1 significantly promotes in vitro osteoblastogenesis

(2016) Yi Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling

(2015) Ting Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2 O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats

(2015) Chao Fu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury

(2014) Ke He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

(2014) X. Meng et al.   FREE RADICAL RESEARCH

Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia

(2014) Anuradha Kalani et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways

(2013) Dan Liang et al.   CELLULAR SIGNALLING

Liquiritigenin Restores Osteoblast Damage through Regulating Oxidative Stress and Mitochondrial Dysfunction

(2013) Eun Mi Choi et al.   PHYTOTHERAPY RESEARCH

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

(2011) Pierre J Marie et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage—implications for the treatment of osteoporosis

(2011) Zhong-Shi Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

Antioxidant status in patients with osteoporosis: A controlled study

(2009) Omer Faruk Sendur et al.   JOINT BONE SPINE

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

Gut, inflammation and osteoporosis: basic and clinical concepts

(2008) H. Tilg et al.   GUT

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY