SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication

Large scale RNA-binding proteins/LncRNAs interaction analysis to uncover lncRNA nuclear localization mechanisms

(2021) Yile Huang et al.   BRIEFINGS IN BIOINFORMATICS

Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction

(2021) Kevin Michael Creamer et al.   MOLECULAR CELL

Clinical findings of 21 previously unreported probands with HNRNPU ‐related syndrome and comprehensive literature review

(2020) Anna Durkin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

γH2AX in the S Phase After UV Irradiation Corresponds to DNA Replication and Does Not Report on the Extent of DNA Damage

(2020) Shivnarayan Dhuppar et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell division requires RNA eviction from condensing chromosomes

(2020) Judith A. Sharp et al.   JOURNAL OF CELL BIOLOGY

Equilibrium between nascent and parental MCM proteins protects replicating genomes

(2020) Hana Sedlackova et al.   NATURE

Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress

(2020) Lora Boteva et al.   Cell Reports

Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing

(2020) Hisashi Miura et al.   Nature Protocols

Structural modularity of the XIST ribonucleoprotein complex

(2020) Zhipeng Lu et al.   Nature Communications

Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

(2019) Eric Moeglin et al.   Cancers

Genome-wide stability of the DNA replication program in single mammalian cells

(2019) Saori Takahashi et al.   NATURE GENETICS

Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

(2019) Javier Garzón et al.   Cell Reports

Role of nuclear RNA in regulating chromatin structure and transcription

(2019) Davide Michieletto et al.   CURRENT OPINION IN CELL BIOLOGY

Localized accumulation of Xist RNA in X chromosome inactivation

(2019) Neil Brockdorff   Open Biology

Replication timing and nuclear structure

(2018) Haiqing Fu et al.   CURRENT OPINION IN CELL BIOLOGY

The role of nuclear matrix protein HNRNPU in maintaining the architecture of 3D genome

(2018) Linlin Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

(2018) Muhammad Shoaib et al.   Nature Communications

The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes

(2017) Hui Fan et al.   GENOME RESEARCH

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

(2017) Yuanliang Zhai et al.   MOLECULAR CELL

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cdt1 stabilizes an open MCM ring for helicase loading

(2017) Jordi Frigola et al.   Nature Communications

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

(2017) Alexis R. Barr et al.   Nature Communications

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells

(2017) Mansi Arora et al.   Cell Reports

Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome

(2017) Mariana Gadaleta et al.   Genes

Deletion ofDXZ4on the human inactive X chromosome alters higher-order genome architecture

(2016) Emily M. Darrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

(2016) Muralidhar L. Hegde et al.   Oncotarget

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

Preventing replication fork collapse to maintain genome integrity

(2015) David Cortez   DNA REPAIR

Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis

(2015) Pauline Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

(2015) Rémi Buisson et al.   MOLECULAR CELL

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function

(2015) Junqiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beanplot: A Boxplot Alternative for Visual Comparison of Distributions

(2015) Peter Kampstra   Journal of Statistical Software

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci

(2014) Daniel Smeets et al.   Epigenetics & Chromatin

Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress

(2013) Kristin M. Zimmerman et al.   MOLECULAR CANCER RESEARCH

BEDOPS: high-performance genomic feature operations

(2012) Shane Neph et al.   BIOINFORMATICS

Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing

(2012) Julien N. Bianco et al.   METHODS

Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation

(2012) Rui Xiao et al.   MOLECULAR CELL

DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair

(2012) M A Serrano et al.   ONCOGENE

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Origin licensing and p53 status regulate Cdk2 activity during G1

(2011) Kathleen R. Nevis et al.   CELL CYCLE

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

(2010) Yuko Hasegawa et al.   DEVELOPMENTAL CELL

Cell fate transitions and the replication timing decision point: Figure 1.

(2010) David M. Gilbert   JOURNAL OF CELL BIOLOGY

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

(2010) Mathieu Tardat et al.   NATURE CELL BIOLOGY

A model for DNA replication showing how dormant origins safeguard against replication fork failure

(2009) J Julian Blow et al.   EMBO REPORTS

Divergent S Phase Checkpoint Activation Arising from Prereplicative Complex Deficiency Controls Cell Survival

(2009) Eric Lau et al.   MOLECULAR BIOLOGY OF THE CELL

ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress

(2008) Rebecca A. Chanoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

(2008) Ichiro Hiratani et al.   PLOS BIOLOGY