3D tumor angiogenesis models: recent advances and challenges

Engineering Vascularized Organoid-on-a-Chip Models

(2021) Venktesh S. Shirure et al.   Annual Review of Biomedical Engineering

Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors

(2020) Mangala Hegde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

(2019) Fanben Meng et al.   ADVANCED MATERIALS

Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)

(2019) Fang‑Tao Wang et al.   Oncology Letters

Organ-on-a-chip technology: turningt its potential for clinical benefit into reality

(2019) Malcolm Haddrick et al.   DRUG DISCOVERY TODAY

Upgrading prevascularization in tissue engineering: A review of strategies for promoting highly organized microvascular network formation

(2019) Dhavan Sharma et al.   Acta Biomaterialia

Micro-injection molded, poly(vinyl alcohol)-calcium salt templates for precise customization of 3D hydrogel internal architecture

(2019) Jason D. McNulty et al.   Acta Biomaterialia

Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

(2019) Annalisa Mercurio et al.   Frontiers in Pharmacology

The Role of the Extracellular Matrix in Cancer Stemness

(2019) Sameera Nallanthighal et al.   Frontiers in Cell and Developmental Biology

Neurotransmitters: emerging targets in cancer

(2019) Shu-Heng Jiang et al.   ONCOGENE

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

(2019) Ruoxiao Xie et al.   Small

Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

(2019) Philipp Wörsdörfer et al.   Scientific Reports

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Recapitulating spatiotemporal tumor heterogeneity in vitro through engineered breast cancer microtissues

(2018) Claudia Mazio et al.   Acta Biomaterialia

Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI

(2018) Simon Walker-Samuel et al.   CANCER RESEARCH

Establishment of an in vitro organoid model of dermal papilla of human hair follicle

(2018) Abhishak C. Gupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis

(2018) Aswath Balakrishnan et al.   LABORATORY INVESTIGATION

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Silk-Based Bioinks for 3D Bioprinting

(2018) Shikha Chawla et al.   Advanced Healthcare Materials

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

(2018) Gianpiero Lazzari et al.   Acta Biomaterialia

Developmental Biology-Inspired Strategies To Engineer 3D Bioprinted Bone Construct

(2018) Shikha Chawla et al.   ACS Biomaterials-Science & Engineering

Cellular and Molecular Heterogeneity Associated with Vessel Formation Processes

(2018) Pollyana Ribeiro Castro et al.   Biomed Research International

Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy

(2017) Natália N. Ferreira et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study

(2017) Khurum Khan et al.   GUT

Diabetes and Wound Angiogenesis

(2017) Uzoagu Okonkwo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks

(2017) Yang Wang et al.   Organogenesis

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Tumor angiogenesis—characteristics of tumor endothelial cells

(2016) Kyoko Hida et al.   International Journal of Clinical Oncology

Advancing biomaterials of human origin for tissue engineering

(2016) Fa-Ming Chen et al.   PROGRESS IN POLYMER SCIENCE

Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation

(2016) Xin Zhao et al.   Oncology Letters

Tumour angiogenesis as a chemo-mechanical surface instability

(2016) Chiara Giverso et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels

(2016) Le-Ping Yan et al.   Scientific Reports

Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis

(2015) Laura J. Bray et al.   BIOMATERIALS

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Co-Culture of Human Endothelial Cells and Foreskin Fibroblasts on 3D Silk-Fibrin Scaffolds Supports Vascularization

(2015) Juhi Samal et al.   MACROMOLECULAR BIOSCIENCE

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering

(2015) Yuting Li et al.   TheScientificWorldJOURNAL

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering

(2015) Yuting Li et al.   Scientific World Journal

Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts

(2014) Qi Xing et al.   ADVANCED FUNCTIONAL MATERIALS

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

(2014) Hyunjae Lee et al.   Biomicrofluidics

Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk

(2014) H. Chen et al.   ENDOCRINE-RELATED CANCER

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Three-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation

(2014) Hamsa Jaganathan et al.   Scientific Reports

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Effects of silk fibroin fiber incorporation on mechanical properties, endothelial cell colonization and vascularization of PDLLA scaffolds

(2013) Matteo Stoppato et al.   BIOMATERIALS

Central and peripheral nervous systems: master controllers in cancer metastasis

(2013) Ming Shi et al.   CANCER AND METASTASIS REVIEWS

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction

(2013) Kristen T. Morin et al.   MICROVASCULAR RESEARCH

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Where to now with the VEGF signalling pathway in cancer?

(2013) Steven A. Stacker et al.   Chinese Journal of Cancer

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels

(2012) Ying-Chieh Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma

(2012) Xiumei Zhao et al.   NEURO-ONCOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Angiogenesis for Treating Cardiovascular Diseases

(2012) Lorenzo Deveza et al.   Theranostics

3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds

(2011) Cunha et al.   International Journal of Nanomedicine

The rapid anastomosis between prevascularized networks on silk fibroin scaffolds generated in vitro with cocultures of human microvascular endothelial and osteoblast cells and the host vasculature

(2010) Ronald E. Unger et al.   BIOMATERIALS

The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

(2010) Dietmar W. Siemann   CANCER TREATMENT REVIEWS

A critical analysis of current in vitro and in vivo angiogenesis assays

(2010) Carolyn A. Staton et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Collagen matrix physical properties modulate endothelial colony forming cell-derived vessels in vivo

(2010) P.J. Critser et al.   MICROVASCULAR RESEARCH

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Extracellular Matrix Proteins and Tumor Angiogenesis

(2010) N. E. Campbell et al.   Journal of Oncology

Paradoxical Effects of PDGF-BB Overexpression in Endothelial Cells on Engineered Blood Vessels In Vivo

(2009) Patrick Au et al.   AMERICAN JOURNAL OF PATHOLOGY

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression Are the Result of Loss of Breast Tissue Polarity

(2009) A. Chen et al.   CANCER RESEARCH

Catecholamines Regulate Tumor Angiogenesis

(2009) D. Chakroborty et al.   CANCER RESEARCH

Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas

(2009) Michael L.H. Wong et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement

(2009) C. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of mechanical boundary conditions on orientation of angiogenic microvessels

(2008) L. Krishnan et al.   CARDIOVASCULAR RESEARCH

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP