The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme

pH-Controlled Protein Orthogonal Ligation Using Asparaginyl Peptide Ligases

(2021) Dingpeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide asparaginyl ligases—renegade peptide bond makers

(2020) James P. Tam et al.   Science China-Chemistry

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

(2020) Junqiao Du et al.   Nature Communications

Insights Into the Role of Exposed Surface Charged Residues in the Alkali-Tolerance of GH11 Xylanase

(2020) Xiuyun Wu et al.   Frontiers in Microbiology

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

(2020) Elfriede Dall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turning an Asparaginyl Endopeptidase into a Peptide Ligase

(2020) Xinya Hemu et al.   ACS Catalysis

A Comprehensive Review on Current Advances in Peptide Drug Development and Design

(2019) Andy Chi-Lung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

(2019) Karen S. Harris et al.   Scientific Reports

Vacuolar processing enzymes in the plant life cycle

(2019) Kenji Yamada et al.   NEW PHYTOLOGIST

Structural analyses ofArabidopsis thalianalegumain γ reveal differential recognition and processing of proteolysis and ligation substrates

(2018) Florian B. Zauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation

(2018) Florian B. Zauner et al.   PLANT CELL

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1

(2018) Thibault J. Harmand et al.   BIOCONJUGATE CHEMISTRY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Bleogens: Cactus-Derived Anti-Candida Cysteine-Rich Peptides with Three Different Precursor Arrangements

(2017) Shining Loo et al.   Frontiers in Plant Science

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Engineering the transposition-based baculovirus expression vector system for higher efficiency protein production from insect cells

(2016) Jennifer L. Mehalko et al.   JOURNAL OF BIOTECHNOLOGY

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

(2015) Karen S. Harris et al.   Nature Communications

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

(2015) William K. Gillette et al.   Scientific Reports

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase-Mediated Biosynthesis

(2012) J. S. Mylne et al.   PLANT CELL

Host-Defense Activities of Cyclotides

(2012) David J. Craik   Toxins

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile

(2011) Elfriede Dall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

(2011) Joshua S Mylne et al.   Nature Chemical Biology

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY