Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ 12,14 PGJ 2

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COX-2 in liver fibrosis

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Lipocalin-type prostaglandin D2 synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease

(2020) Sunil Kumar et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Arachidonic Acid as an Early Indicator of Inflammation during Non-Alcoholic Fatty Liver Disease Development

(2020) Klaudia Sztolsztener et al.   Biomolecules

Design, synthesis and biological evaluation of vortioxetine derivatives as new COX-1/2 inhibitors in human monocytes

(2020) Maria Talmon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hepatic Insulin Clearance: Mechanism and Physiology

(2019) Sonia M. Najjar et al.   PHYSIOLOGY

15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

(2019) Jingjing Li et al.   PPAR Research

Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study

(2019) Qingqing Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring

(2019) Justine Marchix et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression

(2018) Shu-juan Pan et al.   ACTA PHARMACOLOGICA SINICA

Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway

(2018) Wenzhe Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synopsis of arachidonic acid metabolism: A review

(2018) Violette Said Hanna et al.   Journal of Advanced Research

A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease

(2018) Josephine Skat-Rørdam et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives

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Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease

(2017) Flavia A Cimini et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice

(2016) Omar Motiño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

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Depression, Serotonin and Tryptophan

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Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

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Trends and patterns of antidepressant use in children and adolescents from five western countries, 2005–2012

(2016) Christian J. Bachmann et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder

(2016) Zeyad T. Sahli et al.   Expert Opinion on Drug Discovery

Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ

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Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

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Molecular neurobiology of major depressive disorder

(2016) Yong-Ku Kim   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Effects of Psychological Stress on Depression

(2015) Longfei Yang et al.   Current Neuropharmacology

The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)

(2015) Paul E. Greenberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

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Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats

(2015) Nicole E. De Long et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment

(2015) Janaina A. Simplicio et al.   VASCULAR PHARMACOLOGY

Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes

(2014) Jing Xiong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Management of Treatment-Resistant Depression in Children and Adolescents

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CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis inob/obmice

(2013) Fatiha Nassir et al.   JOURNAL OF LIPID RESEARCH

A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer

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The Pharmacoepidemiology of Selective Serotonin Reuptake Inhibitors for Children and Adolescents in Canada from 2005 to 2009: A Database Analysis

(2013) Darren Lam et al.   PEDIATRIC DRUGS

Fluoxetine Induces Hepatic Lipid Accumulation Via Both Promotion of the SREBP1c-Related Lipogenesis and Reduction of Lipolysis in Primary Mouse Hepatocytes

(2012) Xue-Min Feng et al.   CNS Neuroscience & Therapeutics

Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults

(2012) Michael Deuschle   CURRENT OPINION IN PSYCHIATRY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

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Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis

(2012) Janin Henkel et al.   LABORATORY INVESTIGATION

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

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The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings

(2011) A Mallat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults

(2011) A. Pan et al.   DIABETOLOGIA

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fluoxetine Inhibits Inflammatory Response and Bone Loss in a Rat Model of Ligature-Induced Periodontitis

(2011) Luciana S. Branco-de-Almeida et al.   JOURNAL OF PERIODONTOLOGY

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

(2011) Dexiang Liu et al.   NEUROPHARMACOLOGY

Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats

(2011) Vinicius Kannen et al.   TOXICOLOGY LETTERS

Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16

(2011) J M Launay et al.   Translational Psychiatry

Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells

(2010) Marina Maggiora et al.   CELL BIOCHEMISTRY AND FUNCTION

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2in vivo

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An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat

(2010) Tomomi Yamazaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?

(2010) Paloma Martín-Sanz   WORLD JOURNAL OF GASTROENTEROLOGY

Neuroendocrine-Related Adverse Events Associated with Antidepressant Treatment in Children and Adolescents

(2009) Jeanette M. Jerrell   CNS Neuroscience & Therapeutics

COX-2-mediated Inflammation in Fat Is Crucial for Obesity-linked Insulin Resistance and Fatty Liver

(2009) Po-Shiuan Hsieh et al.   Obesity

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27

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MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes

(2008) Claire Z. Larter et al.   JOURNAL OF HEPATOLOGY

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

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