Novel Peptide Motifs Containing Asp-Glu-Gly Target P2Y12 and Thromboxane A2 Receptors to Inhibit Platelet Aggregation and Thrombus Formation

The Pro-Gly or Hyp-Gly Containing Peptides from Absorbates of Fish Skin Collagen Hydrolysates Inhibit Platelet Aggregation and Target P2Y12 Receptor by Molecular Docking

(2021) Qi Tian et al.   Foods

A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y12 Receptor

(2020) Xiaohua Li et al.   CARDIOVASCULAR DRUGS AND THERAPY

Profiling the Protein Targets of Unmodified Bio‐Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry

(2020) Hui‐Yun Hwang et al.   PROTEOMICS

A novel di‐peptide Met‐Glu from collagen hydrolysates inhibits platelet aggregation and thrombus formation via regulation of Gq‐mediated signaling

(2020) Yijie Yang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar

(2020) Yijie Yang et al.   ACS Omega

Ultra-large library docking for discovering new chemotypes

(2019) Jiankun Lyu et al.   NATURE

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction

(2019) Chen Zhang et al.   Jove-Journal of Visualized Experiments

NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice

(2018) Qi Li et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Identification and molecular docking study of novel angiotensin-converting enzyme inhibitory peptides from Salmo salar using in silico methods

(2018) Zhipeng Yu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases

(2018) Jennifer Yeung et al.   PHARMACOLOGICAL REVIEWS

Restored response to ADP downstream of purinergic P2Y12 receptor in apheresis platelets after pathogen-reducing xenon flash treatment

(2018) Hideki Abe et al.   TRANSFUSION

The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin

(2018) Ying Gao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spectrum-Effect Relationships between High-Performance Liquid Chromatography (HPLC) Fingerprints and the Antioxidant and Anti-Inflammatory Activities of Collagen Peptides

(2018) Junwen Wang et al.   MOLECULES

Structural basis for ligand recognition of the human thromboxane A2 receptor

(2018) Hengxin Fan et al.   Nature Chemical Biology

1, 6-di- O -caffeoyl- β - D -glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y 12 and thromboxane A 2 receptor-mediated amplification of platelet activation and aggregation

(2017) Jianjiang Fu et al.   PHYTOMEDICINE

The effect of collagen hydrolysates from silver carp (Hypophthalmichthys molitrix) skin on UV-induced photoaging in mice: molecular weight affects skin repair

(2017) Hongdong Song et al.   Food & Function

Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice

(2017) Hongdong Song et al.   Nutrients

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In VivoNovelty and Significance

(2015) Nicole Urtz et al.   CIRCULATION RESEARCH

Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation by Affecting PI3K/Akt Signaling

(2015) Xing-li Su et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

YY-39, a tick anti-thrombosis peptide containing RGD domain

(2015) Jing Tang et al.   PEPTIDES

Antithrombotic and antiplatelet activities of orientin in vitro and in vivo

(2015) Wonhwa Lee et al.   Journal of Functional Foods

A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates

(2015) Meimei Chen et al.   Scientific Reports

Platelets in Inflammation and Atherogenesis

(2015) Henry M. Nording et al.   Frontiers in Immunology

A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands

(2014) Zhiye Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evaluation of the antithrombotic effects ofCrataegus monogynaandCrataegus davisiiin the carrageenan-induced tail thrombosis model

(2014) Rana Arslan et al.   PHARMACEUTICAL BIOLOGY

Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation

(2014) Marcelo Alarcón et al.   PLATELETS

BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase

(2011) Liang Hu et al.   THROMBOSIS AND HAEMOSTASIS

BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism

(2010) Si Zhang et al.   THROMBOSIS AND HAEMOSTASIS

The P2Y12Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels

(2009) Subhashini Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombolytic effect of Subtilisin QK on carrageenan induced thrombosis model in mice

(2009) Feng Yan et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA