Regulatory Roles of the N-Terminal Intrinsically Disordered Region of Modular Src

Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage

(2021) Adèle Kerjouan et al.   JOURNAL OF CELL SCIENCE

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain

(2021) Ana Ruiz-Saenz et al.   MOLECULAR CANCER RESEARCH

PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

(2021) Sonia T. Nicolaou et al.   Scientific Reports

Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK

(2021) Choon-Soo Lee et al.   Stem Cell Reports

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

(2021) Maria A. Ortiz et al.   Cell Communication and Signaling

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

(2021) Maria Laura Tognoli et al.   EMBO JOURNAL

New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

(2021) Sandra Berndt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration

(2021) Srinivas Ayyadevara et al.   METABOLIC BRAIN DISEASE

Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle

(2021) Miriam Böhm et al.   eLife

Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core

(2020) Mahmoud Shaaban Mohamed et al.   BIOMATERIALS

RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A

(2020) Jae-Gyu Kim et al.   Redox Biology

Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies

(2019) Anne Martinelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions

(2019) Ethan Ahler et al.   MOLECULAR CELL

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

(2019) Mihai L. Azoitei et al.   JOURNAL OF CELL BIOLOGY

Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains

(2019) Miguel Arbesú et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

In Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma

(2018) Liangliang Ren et al.   MOLECULAR & CELLULAR PROTEOMICS

LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

(2018) Yanyan Tang et al.   Molecular Cancer

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src

(2018) Danislav S. Spassov et al.   Cell Reports

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level

(2017) Hai Pan et al.   NUCLEIC ACIDS RESEARCH

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

(2017) Miguel Arbesú et al.   STRUCTURE

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

(2017) Michael Tong et al.   Nature Communications

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

(2017) David P. Scanlon et al.   Nature Communications

Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation

(2017) Antonios D. Konitsiotis et al.   Nature Communications

Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM

(2017) Sarah Keenan et al.   Scientific Reports

A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice

(2017) Kenji Kashiwagi et al.   Scientific Reports

Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis

(2016) Ami Patel et al.   LIFE SCIENCES

The role of cullin 5-containing ubiquitin ligases

(2016) Fumihiko Okumura et al.   Cell Division

The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src

(2015) Sarah Keenan et al.   FEBS LETTERS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src

(2015) Mariano Maffei et al.   STRUCTURE

Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

(2015) Silviya R. Stateva et al.   PLoS One

Multiple Interactions of the Intrinsically Disordered Region between the Helicase and Nuclease Domains of the Archaeal Hef Protein

(2014) Sonoko Ishino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

(2014) Hiroyuki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of unique domains of Src family kinases

(2014) Irene Amata et al.   Frontiers in Genetics

Phosphorylation-Coupled Intramolecular Dynamics of Unstructured Regions in Chromatin Remodeler FACT

(2013) Manami Hashimoto et al.   BIOPHYSICAL JOURNAL

Multi-phosphorylation of the Intrinsically Disordered Unique Domain of c-Src Studied by In-Cell and Real-Time NMR Spectroscopy

(2013) Irene Amata et al.   CHEMBIOCHEM

A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity

(2013) M. Iqbal Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation

(2013) A. Teckchandani et al.   JOURNAL OF CELL SCIENCE

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

(2013) Sevgi Irtegun et al.   PLoS One

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism

(2013) Yolanda Pérez et al.   Scientific Reports

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

The Role of Elongin BC-Containing Ubiquitin Ligases

(2012) Fumihiko Okumura et al.   Frontiers in Oncology

Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)

(2011) Q. Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Calmodulin Mediates Fas-induced FADD-independent Survival Signaling in Pancreatic Cancer Cells via Activation of Src-Extracellular Signal-regulated Kinase (ERK)

(2011) Kaiyu Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions

(2010) Bradley R. Groveman et al.   FEBS Journal

Restriction of Src Activity by Cullin-5

(2009) George S. Laszlo et al.   CURRENT BIOLOGY

Structural Characterization of the Natively Unfolded N-Terminal Domain of Human c-Src Kinase: Insights into the Role of Phosphorylation of the Unique Domain

(2009) Yolanda Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY

Cdk5-Dependent Regulation of Rho Activity, Cytoskeletal Contraction, and Epithelial Cell Migration via Suppression of Src and p190RhoGAP

(2009) B. K. Tripathi et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling

(2008) Mrudula Donepudi et al.   CELLULAR SIGNALLING

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

(2008) Philipp Selenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Characterization of the Active and Inactive States of Src Kinase in Solution by Small-Angle X-ray Scattering

(2007) Pau Bernadó et al.   JOURNAL OF MOLECULAR BIOLOGY

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES