Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

Ubiquitination of Src promotes its secretion via small extracellular vesicles

(2020) Kentaro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

(2020) Dima A. Sabbah et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The physiological role of Wnt pathway in normal development and cancer

(2020) Xiang Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MMPs, tyrosine kinase signaling and extracellular matrix proteolysis in kidney cancer

(2020) Fiza Hashmi et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

(2020) Nora Feldker et al.   EMBO JOURNAL

Structure, Function, and Regulation of the SRMS Tyrosine Kinase

(2020) Chakia J. McClendon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far

(2020) Stefano Martellucci et al.   Cancers

SH2 Domain Binding: Diverse FLVRs of Partnership

(2020) Rachel Jaber Chehayeb et al.   Frontiers in Endocrinology

Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion

(2019) Aida Villarroel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

(2019) Disharee Nath et al.   Cell Communication and Signaling

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

(2018) Victoria K Woodcock et al.   BRITISH JOURNAL OF CANCER

Involvement of partial EMT in cancer progression

(2018) Masao Saitoh   JOURNAL OF BIOCHEMISTRY

Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI

(2018) Chien-Hui Weng et al.   ONCOGENE

Src kinase phosphorylates Notch1 to inhibit MAML binding

(2018) Bryce LaFoya et al.   Scientific Reports

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells

(2018) Ana Sofia Ribeiro et al.   Cell Communication and Signaling

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

IL6 is associated with response to dasatinib and cetuximab: Phase II clinical trial with mechanistic correlatives in cetuximab-resistant head and neck cancer

(2017) L.P. Stabile et al.   ORAL ONCOLOGY

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

(2017) Miguel Arbesú et al.   STRUCTURE

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

(2017) David P. Scanlon et al.   Nature Communications

A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK)

(2016) T. Powles et al.   ANNALS OF ONCOLOGY

Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis

(2016) Ami Patel et al.   LIFE SCIENCES

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

(2016) Silvia Juliana Serrano-Gomez et al.   Molecular Cancer

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin

(2016) Chien-Lin Chen et al.   Oncotarget

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

The potential of Src inhibitors

(2015) Daniel Elias et al.   Aging-US

TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism

(2015) Hongqiao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer

(2015) Pasi A. Jänne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis

(2015) Sébastien Tabariès et al.   Oncotarget

A randomised, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer†

(2014) I. A. McNeish et al.   ANNALS OF ONCOLOGY

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition

(2014) Rik Derynck et al.   CURRENT OPINION IN CELL BIOLOGY

LYN-activating mutations mediate antiestrogen resistance in estrogen receptor–positive breast cancer

(2014) Luis J. Schwarz et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy

(2014) D Elias et al.   ONCOGENE

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Phosphorylation of unique domains of Src family kinases

(2014) Irene Amata et al.   Frontiers in Genetics

A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy

(2013) Przemyslaw W. Twardowski et al.   ANTI-CANCER DRUGS

Multi-phosphorylation of the Intrinsically Disordered Unique Domain of c-Src Studied by In-Cell and Real-Time NMR Spectroscopy

(2013) Irene Amata et al.   CHEMBIOCHEM

Monomeric α-catenin links cadherin to the actin cytoskeleton

(2013) Ridhdhi Desai et al.   NATURE CELL BIOLOGY

Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells

(2013) Karen L. Burger et al.   PROSTATE

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism

(2013) Yolanda Pérez et al.   Scientific Reports

Expression of Wnt3 Activates Wnt/ -Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells

(2012) Y. Wu et al.   MOLECULAR CANCER RESEARCH

Nanometer-Scale Printing

(2012) J. A. Rogers   SCIENCE

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

A Phase 2 Trial of Dasatinib in Patients with Advanced HER2-Positive and/or Hormone Receptor-Positive Breast Cancer

(2011) E. L. Mayer et al.   CLINICAL CANCER RESEARCH

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

(2011) N. S. Nagaraj et al.   CLINICAL CANCER RESEARCH

The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patients

(2011) Tim J Kruser et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration

(2011) Lanfang Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies

(2011) Athanassios Argiris et al.   INVESTIGATIONAL NEW DRUGS

Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation

(2011) D. Yao et al.   MOLECULAR CANCER RESEARCH

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition

(2011) B N Rexer et al.   ONCOGENE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma

(2011) N. Suwaki et al.   Science Translational Medicine

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

(2011) Siyuan Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Significance of ER–Src axis in hormonal therapy resistance

(2010) Sreeram Vallabhaneni et al.   BREAST CANCER RESEARCH AND TREATMENT

Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation

(2010) Ke Liang et al.   CANCER CELL

Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells

(2010) M. A. Matrone et al.   CANCER RESEARCH

Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer

(2010) J. J. Arcaroli et al.   CLINICAL CANCER RESEARCH

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells

(2010) Patrycja M. Dubielecka et al.   FEBS LETTERS

A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer

(2010) Daniel J. Renouf et al.   INVESTIGATIONAL NEW DRUGS

Phase I/II Study of the Src Inhibitor Dasatinib in Combination With Erlotinib in Advanced Non–Small-Cell Lung Cancer

(2010) Eric B. Haura et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Dasatinib in Patients With Advanced Non–Small-Cell Lung Cancer

(2010) Faye M. Johnson et al.   JOURNAL OF CLINICAL ONCOLOGY

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

(2010) E F Dunn et al.   ONCOGENE

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases

(2010) Y Liu et al.   ONCOGENE

ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

(2010) E Sánchez-Tilló et al.   ONCOGENE

Transforming Growth Factor   Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton

(2009) S. E. Wang et al.   CANCER RESEARCH

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells

(2009) X. Sun et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer

(2009) E. Y. Yu et al.   CLINICAL CANCER RESEARCH

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

(2009) L. A. Byers et al.   CLINICAL CANCER RESEARCH

Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells

(2009) Meng-Lei Zhu et al.   FASEB JOURNAL

Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer

(2009) Prateek Mendiratta et al.   JOURNAL OF CLINICAL ONCOLOGY

Structural Characterization of the Natively Unfolded N-Terminal Domain of Human c-Src Kinase: Insights into the Role of Phosphorylation of the Unique Domain

(2009) Yolanda Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Cell-Cell Adhesion by Abi/Diaphanous Complexes

(2009) J. R. Ryu et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential

(2009) R. Marcotte et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear EGFR contributes to acquired resistance to cetuximab

(2009) C Li et al.   ONCOGENE

Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin–proteasome pathway

(2009) Y Yoo et al.   ONCOGENE

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1

(2008) Xiaoling Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

The cell-cell adhesion molecule E-cadherin

(2008) F. van Roy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity

(2008) Kikuko Ikeda et al.   EXPERIMENTAL CELL RESEARCH

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Relevance of Breast Cancer Antiestrogen Resistance Genes in Human Breast Cancer Progression and Tamoxifen Resistance

(2008) Ton van Agthoven et al.   JOURNAL OF CLINICAL ONCOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

(2008) H. Guan et al.   MOLECULAR CANCER THERAPEUTICS

Snail promotes Wnt target gene expression and interacts with β-catenin

(2008) V Stemmer et al.   ONCOGENE

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteome of Resting Human Platelets

(2007) René P. Zahedi et al.   JOURNAL OF PROTEOME RESEARCH

Src kinase regulates metalloproteinase-9 secretion induced by type IV collagen in MCF-7 human breast cancer cells

(2007) P CORTESREYNOSA et al.   MATRIX BIOLOGY