Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

(2021) María Victoria Ruiz-Pérez et al.   iScience

Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs

(2020) Xin Wu et al.   Future Medicinal Chemistry

Marginal band microtubules are acetylated by αTAT1

(2020) Anne-Sophie Ribba et al.   PLATELETS

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin in Platelets: When the Shape Matters

(2019) Ernesto José Cuenca-Zamora et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

(2019) Naim Alkhouri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

(2019) Leyuan Chen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

AMPK-ACC signaling modulates platelet phospholipids content and potentiates platelet function and thrombus formation

(2018) Sophie Lepropre et al.   BLOOD

Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin induced reactive oxygen species generation and platelet activation

(2018) H. Akbar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation

(2018) Juliette van Dijk et al.   BMC BIOLOGY

Peptides derived from cadherin juxtamembrane region inhibit platelet function

(2018) Kalyan Golla et al.   Royal Society Open Science

Lighting up kinase action in platelets

(2017) A. Smolenski   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer

(2017) T. Hiratsuka et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

A phase I study of vorinostat combined with bortezomib in Japanese patients with relapsed or refractory multiple myeloma

(2015) Yoshiaki Ogawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function

(2015) A. Moscardó et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lysine acetyltransfer supports platelet function

(2015) J. E. Aslan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New explanations for old observations: marginal band coiling during platelet activation

(2015) K. Sadoul   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Metabolic Plasticity in Resting and Thrombin Activated Platelets

(2015) Saranya Ravi et al.   PLoS One

Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway

(2014) Francesco Maione et al.   JOURNAL OF ETHNOPHARMACOLOGY

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation

(2013) Joseph E. Aslan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

(2013) Joseph E. Aslan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear

(2013) Joseph E. Aslan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HDAC6 controls the kinetics of platelet activation

(2012) K. Sadoul et al.   BLOOD

Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation

(2012) Camelia Iancu-Rubin et al.   EXPERIMENTAL HEMATOLOGY

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation

(2012) Luciano Galdieri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTPases and their role in organizing the actin cytoskeleton

(2011) S.-T. Sit et al.   JOURNAL OF CELL SCIENCE

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

(2009) D. Pandey et al.   BLOOD

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

(2009) Shundong Cang et al.   Journal of Hematology & Oncology

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

(2008) S. Patel-Hett et al.   BLOOD