Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells

Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway

(2021) Thuy Le Lam Nguyen et al.   ARCHIVES OF PHARMACAL RESEARCH

Ginsenoside-Rg2 affects cell growth via regulating ROS-mediated AMPK activation and cell cycle in MCF-7 cells

(2021) Hyesu Jeon et al.   PHYTOMEDICINE

Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling

(2021) Diem Thi Ngoc Huynh et al.   Cancers

Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells

(2020) Muhammad Zubair Saleem et al.   OncoTargets and Therapy

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression

(2020) Dawei Yang et al.   ARCHIVES OF TOXICOLOGY

IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway

(2020) Yi-Fang Yang et al.   CANCER LETTERS

Therapeutic effects of ginsenosides on breast cancer growth and metastasis

(2020) Yujin Jin et al.   ARCHIVES OF PHARMACAL RESEARCH

Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages

(2020) Diem Thi Ngoc Huynh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling

(2020) Dayoung Ryu et al.   ARCHIVES OF PHARMACAL RESEARCH

CD44 in Ovarian Cancer Progression and Therapy Resistance—A Critical Role for STAT3

(2020) Antons Martincuks et al.   Frontiers in Oncology

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

(2019) Jiang-Jiang Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway

(2019) Bo Peng et al.   PHARMACOLOGICAL RESEARCH

Apoptotic cell clearance in the tumor microenvironment: a potential cancer therapeutic target

(2019) Seong-Ah Shin et al.   ARCHIVES OF PHARMACAL RESEARCH

Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

(2019) José Esparza-López et al.   BMC CANCER

Detection of 13 Ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20(S)-Protopanaxadiol, and 20(S)-Protopanaxatriol) in Human Plasma and Application of the Analytical Method to Human Pharmacokinetic Studies Following Two Week-Repeated Administration of Red Ginseng Extract

(2019) Sojeong Jin et al.   MOLECULES

CAPE-pNO2 Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway

(2019) Qin Huang et al.   Frontiers in Oncology

Ginsenoside Rh1 inhibits colorectal cancer cell migration and invasion in vitro and tumor growth in vivo

(2019) Xi Lyu et al.   Oncology Letters

Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness

(2019) Kha-Liang Lee et al.   Cancers

Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3

(2019) Halima Alsamri et al.   Frontiers in Oncology

Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer

(2019) Lihua Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis

(2019) Yali Li et al.   Frontiers in Pharmacology

Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy

(2018) K. Menke et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review

(2018) Yinzhi Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3

(2018) Xuan Zhang et al.   MOLECULES

Metastatic and triple-negative breast cancer: challenges and treatment options

(2018) Sumayah Al-Mahmood et al.   Drug Delivery and Translational Research

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

(2018) In Jun Yeo et al.   ARCHIVES OF PHARMACAL RESEARCH

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

(2018) Wei Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites

(2016) Xiao-Jia Chen et al.   Evidence-based Complementary and Alternative Medicine

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes

(2016) Xiaofeng Dai et al.   Journal of Cancer

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis

(2015) Sang-Yun Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells

(2014) Kyong-Oh Shin et al.   ARCHIVES OF PHARMACAL RESEARCH

Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells

(2013) Ji-Sun Jung et al.   NEUROCHEMISTRY INTERNATIONAL

Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells

(2012) Ji-Hae Yoon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells

(2010) Mathanaporn Boonrao et al.   ARCHIVES OF PHARMACAL RESEARCH

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL