Biosynthesis and Degradation of Sulfur Modifications in tRNAs

Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications

(2021) Takeshi Chujo et al.   FEBS Journal

The expanding world of tRNA modifications and their disease relevance

(2021) Tsutomu Suzuki   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of RNA Modifications by Second- and Third-Generation Deep Sequencing: 2020 Update

(2021) Yuri Motorin et al.   Genes

Iron–sulfur biology invades tRNA modification: the case of U34 sulfuration

(2021) Jingjing Zhou et al.   NUCLEIC ACIDS RESEARCH

Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate

(2021) Francesca Rapino et al.   Nature Communications

A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery

(2021) Kearsley M. Dillon et al.   ACS Chemical Biology

Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

(2021) Olga A. Esakova et al.   NATURE

Retrograde sulfur flow from glucosinolates to cysteine in Arabidopsis thaliana

(2021) Ryosuke Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

(2020) Roland Lill et al.   Annual Review of Biochemistry

First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-Like Auxiliary Cluster

(2020) Bo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

(2020) Maria C. Ferreira dos Santos et al.   Nature Communications

Synthesis and metabolic fate of 4‐methylthiouridine in bacterial tRNA

(2020) Christoph Borek et al.   CHEMBIOCHEM

The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications

(2020) Simon Rose et al.   NUCLEIC ACIDS RESEARCH

Naturally occurring modified ribonucleosides

(2020) Phillip J. McCown et al.   Wiley Interdisciplinary Reviews-RNA

Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family

(2020) Baofang Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural evidence for a [4Fe‐5S] intermediate in the non‐redox desulfuration of thiouracil

(2020) Jingjing Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular basis for the bifunctional Uba4–Urm1 sulfur‐relay system in tRNA thiolation and ubiquitin‐like conjugation

(2020) Marta Pabis et al.   EMBO JOURNAL

Reversal of nucleobase methylation by dioxygenases

(2020) Guo-Liang Xu et al.   Nature Chemical Biology

Structure-based mechanistic insights into catalysis by tRNA thiolation enzymes

(2020) Ornella Bimai et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA

(2019) Satoshi Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ancient type of MnmA protein is an iron–sulfur cluster-dependent sulfurtransferase for tRNA anticodons

(2019) Naoki Shigi et al.   RNA

NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli

(2019) Valentin F. Reichle et al.   Nature Communications

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure

(2018) Christina Dal Magro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytochrome c Catalyzes the Hydrogen Peroxide-Assisted Oxidative Desulfuration of 2-Thiouridines in Transfer RNAs

(2018) Małgorzata Sierant et al.   CHEMBIOCHEM

A gene encoding a DUF523 domain protein is involved in the conversion of 2-thiouracil into uracil

(2018) Agota Aučynaitė et al.   Environmental Microbiology Reports

Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum

(2018) Matthias Fellner et al.   BIOCHEMISTRY

Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

Metallocluster transactions: dynamic protein interactions guide the biosynthesis of Fe–S clusters in bacteria

(2018) Chenkang Zheng et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A structural perspective on the PP-loop ATP pyrophosphatase family

(2018) Matthias Fellner et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Recent Advances in Our Understanding of the Biosynthesis of Sulfur Modifications in tRNAs

(2018) Naoki Shigi   Frontiers in Microbiology

Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA

(2017) Minghao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster

(2017) Simon Arragain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE

(2017) Matthias Fellner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

(2017) Takaaki Akaike et al.   Nature Communications

Identification of a rhodanese-like protein involved in thiouridine biosynthesis inThermus thermophilustRNA

(2016) Naoki Shigi et al.   FEBS LETTERS

A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes

(2016) Yuchen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the catalytic disulfide bond in E. coli 4-thiouridine synthetase to elucidate its functional quaternary structure

(2016) Govardhan Reddy Veerareddygari et al.   PROTEIN SCIENCE

Emerging concepts in the therapy of mitochondrial disease

(2015) Carlo Viscomi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Auxiliary iron–sulfur cofactors in radical SAM enzymes

(2015) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The influence of the C5 substituent on the 2-thiouridine desulfuration pathway and the conformational analysis of the resulting 4-pyrimidinone products

(2015) Paulina Bartos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Cdk5rap1-Mediated 2-Methylthio Modification of Mitochondrial tRNAs Governs Protein Translation and Contributes to Myopathy in Mice and Humans

(2015) Fan-Yan Wei et al.   Cell Metabolism

Oxidative stress in inherited mitochondrial diseases

(2015) Genki Hayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abbreviated Pathway for Biosynthesis of 2-Thiouridine in Bacillus subtilis

(2015) Katherine A. Black et al.   JOURNAL OF BACTERIOLOGY

A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase

(2015) B. Desguin et al.   SCIENCE

Crystal structure of a 4-thiouridine synthetase–RNA complex reveals specificity of tRNA U8 modification

(2014) Piotr Neumann et al.   NUCLEIC ACIDS RESEARCH

TtcA a new tRNA-thioltransferase with an Fe-S cluster

(2014) Denis Bouvier et al.   NUCLEIC ACIDS RESEARCH

Archaeal Tuc1/Ncs6 Homolog Required for Wobble Uridine tRNA Thiolation Is Associated with Ubiquitin-Proteasome, Translation, and RNA Processing System Homologs

(2014) Nikita E. Chavarria et al.   PLoS One

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and functions of sulfur modifications in tRNA

(2014) Naoki Shigi   Frontiers in Genetics

Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6–7.6 is pH-dependent and results in two distinct products

(2013) Elzbieta Sochacka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Sulfur Carrier Protein TusA Has a Pleiotropic Role inEscherichia coliThat Also Affects Molybdenum Cofactor Biosynthesis

(2013) Jan-Ulrik Dahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of an Intermediate Methyl Carrier in the Radical S-Adenosylmethionine Methylthiotransferases RimO and MiaB

(2013) Bradley J. Landgraf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases

(2013) Farhad Forouhar et al.   Nature Chemical Biology

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA

(2013) Hirofumi Nakagawa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

Posttranslational Modification of Cellular Proteins by a Ubiquitin-like Protein in Bacteria

(2012) Naoki Shigi   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of 4-Thiouridine in tRNA in the Methanogenic ArchaeonMethanococcus maripaludis

(2012) Yuchen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting

(2012) Nathaniel D Maynard et al.   Molecular Systems Biology

Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors

(2011) Ryota Hidese et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice

(2011) Fan-Yan Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA

(2010) Simon Arragain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural aspects of messenger RNA reading frame maintenance by the ribosome

(2010) Lasse B Jenner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

(2010) Rong Shi et al.   PLOS BIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

(2009) Akiko Noma et al.   NUCLEIC ACIDS RESEARCH

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis

(2009) Eugene G. Mueller et al.   PROTEIN SCIENCE

Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors

(2008) Naoki Shigi et al.   EMBO JOURNAL

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

(2008) M. Dewez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli

(2008) B. P. Anton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA