Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

(2021) Akanksha Roy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development

(2021) Soumyaparna Das et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells

(2021) Concetta Scimone et al.   EXPERIMENTAL EYE RESEARCH

Fumonisin B1 induces poly (ADP-ribose) (PAR) polymer-mediated cell death (parthanatos) in neuroblastoma

(2021) Souren Paul et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidative Stress and the Neurovascular Unit

(2021) Carmela Rinaldi et al.   Life-Basel

mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors

(2020) Yi-Ran Pan et al.   Cell Communication and Signaling

The significance of exosomes in the development and treatment of hepatocellular carcinoma

(2020) Xin Li et al.   Molecular Cancer

Calpain-2 participates in the process of calpain-1 inactivation

(2020) Fumiko Shinkai-Ouchi et al.   BIOSCIENCE REPORTS

Suppressing PAR ylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death

(2020) Anna Kondratova et al.   EMBO JOURNAL

Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice

(2020) Lorena Olivares‐González et al.   FASEB JOURNAL

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

(2020) Husvinee Sundaramurthi et al.   Frontiers in Cell and Developmental Biology

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia

(2020) Mirja Koch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New Omics—Derived Perspectives on Retinal Dystrophies: Could Ion Channels-Encoding or Related Genes Act as Modifier of Pathological Phenotype?

(2020) Luigi Donato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular mechanisms of hereditary photoreceptor degeneration – Focus on cGMP

(2019) Michael Power et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration

(2019) Ayse Sahaboglu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

(2019) Michael M. Murata et al.   MOLECULAR BIOLOGY OF THE CELL

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

(2019) Nirmal Robinson et al.   Redox Biology

Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration

(2019) Michael J. Power et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI

(2018) Bruce A. Berkowitz   JOURNAL OF MAGNETIC RESONANCE

GUCY2D Cone–Rod Dystrophy-6 Is a “Phototransduction Disease” Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1

(2018) Shinya Sato et al.   JOURNAL OF NEUROSCIENCE

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

(2018) Eleonora Vighi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

(2018) Dimitra Athanasiou et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

(2018) Jacque L. Duncan et al.   Translational Vision Science & Technology

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer

(2018) Daniele Bano et al.   EBioMedicine

Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro

(2018) Hanhui Zhong et al.   Cell Death & Disease

Two pathways of rod photoreceptor cell death induced by elevated cGMP

(2017) Tian Wang et al.   HUMAN MOLECULAR GENETICS

EYS mutation update: In silico assessment of 271 reported and 26 novel variants in patients with retinitis pigmentosa

(2017) Muriël Messchaert et al.   HUMAN MUTATION

Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34

(2017) Ayse Sahaboglu et al.   PLoS One

New cGMP analogues restrain proliferation and migration of melanoma cells

(2017) Eleonora Vighi et al.   Oncotarget

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Glycolytic reliance promotes anabolism in photoreceptors

(2017) Yashodhan Chinchore et al.   eLife

Calcium dynamics change in degenerating cone photoreceptors

(2016) Manoj Kulkarni et al.   HUMAN MOLECULAR GENETICS

HDAC inhibition in thecpfl1mouse protects degenerating cone photoreceptorsin vivo

(2016) Dragana Trifunović et al.   HUMAN MOLECULAR GENETICS

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein

(2016) Igor V. Peshenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration

(2016) Lijuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma

(2016) Rikke D. Rasmussen et al.   Molecular Oncology

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration

(2016) Michel Baudry et al.   TRENDS IN NEUROSCIENCES

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

(2016) Ayse Sahaboglu et al.   Scientific Reports

Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

(2016) Christian Schön et al.   PLoS One

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

(2015) Aditya Venkatesh et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

(2015) James B. Hurley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

PARPs and ADP-Ribosylation: 50 Years … and Counting

(2015) W. Lee Kraus   MOLECULAR CELL

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation

(2015) Eva Barkauskaite et al.   MOLECULAR CELL

Readers of poly(ADP-ribose): designed to be fit for purpose

(2015) Federico Teloni et al.   NUCLEIC ACIDS RESEARCH

Novel In Situ Activity Assays for the Quantitative Molecular Analysis of Neurodegenerative Processes in the Retina

(2014) P.A.R. Ekstrom et al.   CURRENT MEDICINAL CHEMISTRY

Prevalence of Generalized Retinal Dystrophy in Denmark

(2014) Mette Bertelsen et al.   OPHTHALMIC EPIDEMIOLOGY

Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration

(2014) Blanca Arango-Gonzalez et al.   PLoS One

Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations

(2014) J.-A. Sahel et al.   Cold Spring Harbor Perspectives in Medicine

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa

(2013) Cristina Martínez-Fernández de la Cámara et al.   PLoS One

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

(2012) Mirko Jaumann et al.   NATURE MEDICINE

Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats

(2011) Jasvir Kaur et al.   PLoS One

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex

(2011) Yan Hao et al.   PLoS Genetics

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

Phototransduction and the Evolution of Photoreceptors

(2010) Gordon L. Fain et al.   CURRENT BIOLOGY

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa

(2010) François Paquet-Durand et al.   HUMAN MOLECULAR GENETICS

cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina

(2010) Dragana Trifunović et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

(2010) Ayse Sahaboglu et al.   PLoS One

Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

(2010) J Sancho-Pelluz et al.   Cell Death & Disease

Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria

(2009) Taku Ozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

(2009) Yingfei Wang et al.   EXPERIMENTAL NEUROLOGY

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Bax-Induced Apoptosis in Leber's Congenital Amaurosis: A Dual Role in Rod and Cone Degeneration

(2009) Séverine Hamann et al.   PLoS One

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light

(2008) Haruhisa Okawa et al.   CURRENT BIOLOGY

Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, resulting in achromatopsia

(2008) Peggy Reuter et al.   HUMAN MUTATION

PKG activity causes photoreceptor cell death in two retinitis pigmentosa models

(2008) François Paquet-Durand et al.   JOURNAL OF NEUROCHEMISTRY

Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

(2008) Javier Sancho-Pelluz et al.   MOLECULAR NEUROBIOLOGY