NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Cancer Stem Cell Metabolism and Potential Therapeutic Targets

(2018) Vusala Snyder et al.   Frontiers in Oncology

Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair

(2018) Xiangduo Kong et al.   JOURNAL OF CELL SCIENCE

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration

(2017) Ki-Hong Jang et al.   Cell Death & Disease

Biosensor reveals multiple sources for mitochondrial NAD+

(2016) X. A. Cambronne et al.   SCIENCE

Measurements of absolute concentrations of NADH in cells using the phasor FLIM method

(2016) Ning Ma et al.   Biomedical Optics Express

The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells

(2016) Vijesh J. Bhute et al.   Scientific Reports

Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable

(2016) Yang Xiao et al.   PLoS One

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris

(2015) Yumay Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells

(2015) Vijesh J. Bhute et al.   Metabolomics

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

(2015) Felix Y. Feng et al.   MOLECULAR CELL

Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites

(2015) Gladys Mae Saquilabon Cruz et al.   NUCLEIC ACIDS RESEARCH

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

DNA Damage to a Single Chromosome End Delays Anaphase Onset

(2014) Bárbara Alcaraz Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

(2014) H. Khoury-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD + Depletion

(2014) Elise Fouquerel et al.   Cell Reports

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy

(2013) Claudia Gey et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

(2013) Barbara Meyer et al.   NUCLEIC ACIDS RESEARCH

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

(2013) H. Kioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Imaging Using Endogenous Contrast to Assess Metabolic State

(2012) Irene Georgakoudi et al.   Annual Review of Biomedical Engineering

NADH Distribution in Live Progenitor Stem Cells by Phasor-Fluorescence Lifetime Image Microscopy

(2012) Belinda K. Wright et al.   BIOPHYSICAL JOURNAL

Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy

(2012) Chiara Stringari   JOURNAL OF BIOMEDICAL OPTICS

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL

(2012) G L Robinson et al.   ONCOGENE

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH

(2012) Chiara Stringari et al.   Scientific Reports

Damage site chromatin: open or closed?

(2011) Alexander R Ball et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

(2011) Xiangduo Kong et al.   PLoS One

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

(2010) Ahmed A Heikal   Biomarkers in Medicine

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation

(2010) Veronica Gomez-Godinez et al.   NUCLEIC ACIDS RESEARCH

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

(2009) Xiangduo Kong et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

The Phasor Approach to Fluorescence Lifetime Imaging Analysis

(2007) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL