Silencing ROCK1 ameliorates ventilator-induced lung injury in mice by inhibiting macrophages’ NLRP3 signaling

Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis

(2020) Arpan Sharma Neupane et al.   CELL

Protective role of p120‐catenin on mitochondria by inhibiting NLRP3 in ventilator‐induced lung injury

(2019) Ge Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alveolar Macrophages

(2018) Nikita Joshi et al.   CELLULAR IMMUNOLOGY

Astragalus membranaceus and Salvia miltiorrhiza Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating the Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway

(2018) Li Qin et al.   Evidence-based Complementary and Alternative Medicine

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory

(2018) Moritz M. Gaidt et al.   JOURNAL OF MOLECULAR BIOLOGY

LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

(2018) Yanyan Tang et al.   Molecular Cancer

Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy

(2018) Shigeru Kinoshita et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microvesicles packaging IL-1β and TNF-α enhance lung inflammatory response to mechanical ventilation in part by induction of cofilin signaling

(2018) Suisui Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

(2017) Jingkao Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

(2017) Kazuhiro Tamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line

(2017) Man Luo et al.   MOLECULAR IMMUNOLOGY

Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats

(2017) Andrzej Wróbel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton

(2017) Lifeng Yang et al.   TOXICOLOGY

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

(2017) Xuan Li et al.   Nature Communications

GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury

(2017) Lei Yi et al.   Frontiers in Cellular and Infection Microbiology

Glycyrrhizin Ameliorate Ischemia Reperfusion Lung Injury through Downregulate TLR2 Signaling Cascade in Alveolar Macrophages

(2017) Lin Fei et al.   Frontiers in Pharmacology

Endothelin-1–Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups

(2016) Jason Gien et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE

(2016) Cristina Rozo et al.   ANNALS OF THE RHEUMATIC DISEASES

Rho Kinases in Autoimmune Diseases

(2016) Alessandra B. Pernis et al.   Annual Review of Medicine

Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability

(2016) Lijun Du et al.   Gastroenterology Research and Practice

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

(2016) Martin A. Bewley et al.   PLoS One

Role of connexin 43 in vascular hyperpermeability and relationship to Rock1-MLC20 pathway in septic rats

(2015) Jie Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency

(2015) David I. Kasahara et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

(2015) Svenja Hartmann et al.   Frontiers in Pharmacology

The role of Rho-kinases in IL-1β release through phagocytosis of fibrous particles in human monocytes

(2014) Sanae Kanno et al.   ARCHIVES OF TOXICOLOGY

Synergy between Rho signaling and matrix density in cyclic stretch-induced stress fiber organization

(2013) Jasper Foolen et al.   Acta Biomaterialia

SC5b-9-Induced Pulmonary Microvascular Endothelial Hyperpermeability Participates in Ventilator-Induced Lung Injury

(2013) Kan Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Rho-associated coiled-coil kinase (ROCK) signaling and disease

(2013) Alice V. Schofield et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

(2012) Maria T. Kuipers et al.   ANESTHESIOLOGY

Role of Rho kinase isoforms in murine allergic airway responses

(2011) M. Zhu et al.   EUROPEAN RESPIRATORY JOURNAL

Essential Role of Cofilin-1 in Regulating Thrombin-induced RelA/p65 Nuclear Translocation and Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Endothelial Cells

(2009) Fabeha Fazal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of cell-cell contacts induces NF-κB via RhoA-mediated activation of protein kinase D1

(2009) Catherine F. Cowell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY