Simultaneous Modulation of NLRP3 Inflammasome and Nrf2/ARE Pathway Rescues Thioacetamide-Induced Hepatic Damage in Mice: Role of Oxidative Stress and Inflammation

IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

(2020) Zhongjie Yi et al.   HEPATOLOGY

Dimethyl fumarate protects thioacetamide‐induced liver damage in rats: Studies on Nrf2, NLRP3, and NF‐κB

(2020) Durgesh K. Dwivedi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production

(2020) Paula Constanza Arriola Benitez et al.   Frontiers in Immunology

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Sadaf G Sepanlou et al.   Lancet Gastroenterology & Hepatology

Androgen aggravates liver fibrosis by activation of NLRP3 inflammasome in CCl4-induced liver injury mouse model

(2020) Xingyu Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species

(2020) Feng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zinc and selenium combination treatment protected diabetes-induced testicular and epididymal damage in rat

(2020) C Sahu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice

(2020) Qun Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence

(2020) Surya Narayan Pandey et al.   PSYCHOPHARMACOLOGY

Zinc deficient diet increases the toxicity of bisphenol A in rat testis

(2020) Chittaranjan Sahu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

NLRP3 inhibition improves heart function in GPER knockout mice

(2019) Hao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide

(2019) Durgesh Kumar Dwivedi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Ethanol-induced gastric ulcer in rats and intervention of tert-butylhydroquinone: Involvement of Nrf2/HO-1 signalling pathway

(2019) Z Rahman et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway

(2019) Durgesh Kumar Dwivedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring

(2018) Yu-Ju Lin et al.   Oxidative Medicine and Cellular Longevity

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation

(2018) Durgesh Kumar Dwivedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

(2018) Jack P. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose

(2018) Chun Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway

(2018) Rehab S. Abdelrahman et al.   LIFE SCIENCES

Interleukin-10 secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis

(2017) Jinglin Wang et al.   HEPATOLOGY RESEARCH

Dimethyl Fumarate Modulates Oxidative Stress and Inflammation in Organs After Sepsis in Rats

(2017) Amanda Della Giustina et al.   INFLAMMATION

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

A Protective Role of Glibenclamide in Inflammation-Associated Injury

(2017) Gensheng Zhang et al.   MEDIATORS OF INFLAMMATION

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury

(2016) Huafeng Wang et al.   Scientific Reports

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes

(2015) Sorina Georgiana Boaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fumaric acid esters prevent the NLRP3 inflammasome-mediated and ATP-triggered pyroptosis of differentiated THP-1 cells

(2015) Gianluca Miglio et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Standard Operating Procedures in Experimental Liver Research: Thioacetamide model in mice and rats

(2015) MC Wallace et al.   LABORATORY ANIMALS

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats

(2015) Danish Ahmed et al.   SpringerPlus

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Glyburide Reduces Bacterial Dissemination in a Mouse Model of Melioidosis

(2013) Gavin C. K. W. Koh et al.   PLoS Neglected Tropical Diseases

Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats

(2011) Cíntia de David et al.   TOXICOLOGIC PATHOLOGY

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY