Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

Paradigms on Immunotherapy Combinations with Chemotherapy

(2021) Diego Salas-Benito et al.   Cancer Discovery

Recruiting T cells in cancer immunotherapy

(2021) Kathryn E. Yost et al.   SCIENCE

Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme

(2021) Maria Teresa Pallotta et al.   FEBS Journal

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

(2021) Yousef Zakharia et al.   Journal for ImmunoTherapy of Cancer

Targeting immunosuppression by TGF-β1 for cancer immunotherapy

(2021) Grégoire de Streel et al.   BIOCHEMICAL PHARMACOLOGY

Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells

(2020) Sanjay Varikuti et al.   BRITISH JOURNAL OF CANCER

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

(2020) Anthony R. Cillo et al.   IMMUNITY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer

(2020) Michael Overman et al.   Journal for ImmunoTherapy of Cancer

Dendritic cells, the T cell-inflamed tumor microenvironment and immunotherapy treatment response

(2020) Christopher S. Garris et al.   CLINICAL CANCER RESEARCH

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

(2020) Cedric Bosteels et al.   IMMUNITY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Dendritic Cells and Their Role in Immunotherapy

(2020) Alycia Gardner et al.   Frontiers in Immunology

Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility

(2020) Rabindra K. Mandal et al.   BMC BIOLOGY

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

(2020) Pierre Bourdely et al.   IMMUNITY

Decoding the Heterogeneity of Human Dendritic Cell Subsets

(2020) Javiera Villar et al.   TRENDS IN IMMUNOLOGY

Improving reproducibility in animal research by splitting the study population into several ‘mini-experiments’

(2020) Vanessa Tabea von Kortzfleisch et al.   Scientific Reports

Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell–Mediated Tumor Regression in the MB49 Bladder Cancer Model

(2019) Sonia Domingos-Pereira et al.   Cancer Immunology Research

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification

(2019) Vivek Durai et al.   NATURE IMMUNOLOGY

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

ENERGIZE: a Phase III study of neoadjuvant chemotherapy alone or with nivolumab with/without linrodostat mesylate for muscle-invasive bladder cancer

(2019) Guru Sonpavde et al.   Future Oncology

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c + CD103 + Monocytic Antigen-Presenting Cells in Tumors

(2018) Madhav D. Sharma et al.   IMMUNITY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

(2018) Sean D. Reiff et al.   Cancer Discovery

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity

(2018) Sreekumar Balan et al.   Cell Reports

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

(2016) Andrew Stiff et al.   CANCER RESEARCH

c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor

(2016) Ravindra Gujar et al.   JOURNAL OF IMMUNOLOGY

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

(2015) M. D. Sharma et al.   Science Advances

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

(2013) Madhav D. Sharma et al.   IMMUNITY

Origin of monocytes and macrophages in a committed progenitor

(2013) Jan Hettinger et al.   NATURE IMMUNOLOGY

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

(2012) Metamia Ciampricotti et al.   NATURE MEDICINE

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

(2012) B. Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation

(2008) Seung-Shick Shin et al.   Pigment Cell & Melanoma Research

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

(2008) C. Orabona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE