Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies

An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein

(2021) Lucie Jelínková et al.   npj Vaccines

Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein

(2021) J. Mauricio Calvo-Calle et al.   npj Vaccines

A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development

(2021) Erwan Atcheson et al.   npj Vaccines

Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

(2021) Joseph R. Francica et al.   Vaccines

A Monoclonal Antibody for Malaria Prevention

(2021) Martin R. Gaudinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

(2020) Rama Raghunandan et al.   MALARIA JOURNAL

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

(2020) Rajagopal Murugan et al.   NATURE MEDICINE

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

(2020) David Oyen et al.   PLoS Pathogens

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

(2020) Hayley A. McNamara et al.   Cell Host & Microbe

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

(2020) Lawrence T. Wang et al.   IMMUNITY

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

(2020) Deli Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors

(2020) Xuesong Wang et al.   EMBO JOURNAL

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

(2020) Neville Kielau Kisalu et al.   JCI Insight

Commonality despite exceptional diversity in the baseline human antibody repertoire

(2019) Bryan Briney et al.   NATURE

High frequency of shared clonotypes in human B cell receptor repertoires

(2019) Cinque Soto et al.   NATURE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence

(2019) Yicheng Guo et al.   Frontiers in Immunology

Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages

(2019) Yevel Flores-Garcia et al.   MALARIA JOURNAL

From human antibody structure and function towards the design of a novel Plasmodium falciparum circumsporozoite protein malaria vaccine

(2018) Hedda Wardemann et al.   CURRENT OPINION IN IMMUNOLOGY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

(2018) Joshua Tan et al.   NATURE MEDICINE

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

(2018) Neville K Kisalu et al.   NATURE MEDICINE

Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity

(2018) Pia Dosenovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

(2018) Katharina Imkeller et al.   SCIENCE

When designing vaccines, consider the starting material: the human B cell repertoire

(2018) Colin Havenar-Daughton et al.   CURRENT OPINION IN IMMUNOLOGY

One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice

(2018) Ying‐Cing Lin et al.   EMBO JOURNAL

The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies

(2018) Joshua Tan et al.   Annual Review of Immunology

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

(2018) Ian A. Cockburn et al.   NATURE IMMUNOLOGY

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

(2017) Gianna Triller et al.   IMMUNITY

Structural basis for antibody recognition of the NANP repeats inPlasmodium falciparumcircumsporozoite protein

(2017) David Oyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

(2017) Camilla R. Fisher et al.   PLoS Pathogens

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

(2017) Zizhang Sheng et al.   Frontiers in Immunology

Malaria

(2017) Margaret A. Phillips et al.   Nature Reviews Disease Primers

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells

(2016) Lotta von Boehmer et al.   Nature Protocols

SeqFeatR for the Discovery of Feature-Sequence Associations

(2016) Bettina Budeus et al.   PLoS One

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

(2014) Michael T White et al.   BMC Medicine

IMGT®, the international ImMunoGeneTics information system® 25 years on

(2014) Marie-Paule Lefranc et al.   NUCLEIC ACIDS RESEARCH

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

(2013) Lander Foquet et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cells from Knock-in Mice Expressing Broadly Neutralizing HIV Antibody b12 Carry an Innocuous B Cell Receptor Responsive to HIV Vaccine Candidates

(2013) T. Ota et al.   JOURNAL OF IMMUNOLOGY

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

(2013) R. A. Seder et al.   SCIENCE

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling

(2011) Olgun Guvench et al.   Journal of Chemical Theory and Computation

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

(2011) Po-Ssu Huang et al.   PLoS One