Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

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Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

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New Hypothesis for the Etiology of SPAST‐ based Hereditary Spastic Paraplegia

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Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

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ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic

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Predicted Effects of Severing Enzymes on the Length Distribution and Total Mass of Microtubules

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Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia

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TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

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Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice

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Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation

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Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse

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Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation

(2017) Lanfranco Leo et al.   HUMAN MOLECULAR GENETICS

Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin

(2017) Joanna M. Solowska et al.   MOLECULAR BIOLOGY OF THE CELL

CatWalk gait analysis in a rat model of multiple sclerosis

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Microtubules in health and degenerative disease of the nervous system

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Stability properties of neuronal microtubules

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Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms

(2016) Carl Julien et al.   HUMAN MOLECULAR GENETICS

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Gait Patterns in Patients with Hereditary Spastic Paraparesis

(2016) Mariano Serrao et al.   PLoS One

The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders

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Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

Hereditary spastic paraplegia SPG4: what is known and not known about the disease

(2015) Joanna M. Solowska et al.   BRAIN

Tubulin acetylation: responsible enzymes, biological functions and human diseases

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Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

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Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative Diseases

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Detection of subtle neurological alterations by the Catwalk XT gait analysis system

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Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

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Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

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HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation

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An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

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Loss of Spastin Function Results in Disease-Specific Axonal Defects in Human Pluripotent Stem Cell-Based Models of Hereditary Spastic Paraplegia

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A novel role for retrograde transport of microtubules in the axon

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Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

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Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress

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Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

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Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

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Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

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Hereditary spastic paraplegias: membrane traffic and the motor pathway

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Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

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Tubulin modifications and their cellular functions

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Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

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