Central Nervous System Metastases

Trastuzumab Emtansine (T-DM1) and stereotactic radiation in the management of HER2+ breast cancer brain metastases

(2021) Matthew N. Mills et al.   BMC CANCER

Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review

(2021) Clark Chen et al.   JOURNAL OF NEURO-ONCOLOGY

T cell circuits that sense antigen density with an ultrasensitive threshold

(2021) Rogelio A. Hernandez-Lopez et al.   SCIENCE

Current approaches to the management of brain metastases

(2020) John H. Suh et al.   Nature Reviews Clinical Oncology

Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer

(2020) Todd M. Bauer et al.   Targeted Oncology

Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases

(2020) Rachel M. Glicksman et al.   JAMA Oncology

Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial

(2020) Nancy U. Lin et al.   JOURNAL OF CLINICAL ONCOLOGY

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial

(2020) Sarah B Goldberg et al.   LANCET ONCOLOGY

Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

(2020) David J. H. Shih et al.   NATURE GENETICS

Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

(2020) Priscilla K. Brastianos et al.   NATURE MEDICINE

Post-operative radiation therapy to the surgical cavity with standard fractionation in patients with brain metastases

(2020) James D. Byrne et al.   Scientific Reports

Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial☆

(2020) F. Montemurro et al.   ANNALS OF ONCOLOGY

Brigatinib Versus Crizotinib in Advanced ALK Inhibitor–Naive ALK-Positive Non–Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial

(2020) D. Ross Camidge et al.   JOURNAL OF CLINICAL ONCOLOGY

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

(2020) Erin N. Howe et al.   Nature Communications

Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective

(2020) Camille Verry et al.   Science Advances

Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis

(2020) Dhiego Chaves de Almeida Bastos et al.   CANCER LETTERS

Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient

(2020) Paul W. Sperduto et al.   JOURNAL OF CLINICAL ONCOLOGY

Emerging Immunotherapies in the Treatment of Brain Metastases

(2020) Edwin Nieblas‐Bedolla et al.   ONCOLOGIST

Whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases: a multicenter, open-label, randomized, controlled phase III trial

(2020) Zhenzhou Yang et al.   NEURO-ONCOLOGY

First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

(2020) Alice T. Shaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brain metastases

(2019) Achal Singh Achrol et al.   Nature Reviews Disease Primers

Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis

(2019) Hye Seon Kim et al.   World Journal of Surgical Oncology

Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

(2019) Adrienne Boire et al.   NEURO-ONCOLOGY

TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases

(2019) Rachel A. Freedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study

(2019) Frederic Bludau et al.   BMC CANCER

Neurophysiological monitoring during neurosurgery

(2019) Benjamin F. Gruenbaum et al.   Current Opinion in Anesthesiology

Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy

(2019) Thuy T. Tran et al.   Journal for ImmunoTherapy of Cancer

Advances in personalized treatment of metastatic spine disease

(2019) Pouyan Ahangar et al.   Annals of Translational Medicine

Brain Metastasis From Renal-Cell Carcinoma: An Institutional Study

(2019) Alfredo Suarez-Sarmiento et al.   Clinical Genitourinary Cancer

Minimally Invasive Separation Surgery for Metastases in the Vertebral Column: A Technical Report

(2019) Rafael A Vega et al.   Operative Neurosurgery

Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials

(2019) Alexander Drilon et al.   LANCET ONCOLOGY

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

(2019) Rashmi K. Murthy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

(2019) Shanu Modi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study

(2018) S Novello et al.   ANNALS OF ONCOLOGY

T-DM1 and brain metastases: clinical outcome in HER2-positive metastatic breast cancer

(2018) Alessandra Fabi et al.   BREAST

Non–small-cell Lung Cancer With Brain Metastasis at Presentation

(2018) Saiama N. Waqar et al.   Clinical Lung Cancer

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update

(2018) Naren Ramakrishna et al.   JOURNAL OF CLINICAL ONCOLOGY

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study

(2018) Georgina V Long et al.   LANCET ONCOLOGY

Leptomeningeal metastases in non-small-cell lung cancer

(2018) Haiying Cheng et al.   LANCET ONCOLOGY

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

(2018) Jean-Charles Soria et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

(2018) Adel Samson et al.   Science Translational Medicine

Alectinib versus crizotinib in treatment-naïve anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study

(2018) S Gadgeel et al.   ANNALS OF ONCOLOGY

Combinations of Bevacizumab With Cancer Immunotherapy

(2018) Daniel S. Chen et al.   CANCER JOURNAL

CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

(2018) Thanyanan Reungwetwattana et al.   JOURNAL OF CLINICAL ONCOLOGY

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

(2018) Hussein A. Tawbi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Awake craniotomy for resection of brain metastases: A systematic review

(2018) Tzy Harn Chua et al.   World Neurosurgery

Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases

(2018) Balamurugan Vellayappan et al.   Frontiers in Oncology

Preservation of Neurocognitive Function (NCF) with Conformal Avoidance of the Hippocampus during Whole-Brain Radiotherapy (HA-WBRT) for Brain Metastases: Preliminary Results of Phase III Trial NRG Oncology CC001

(2018) V. Gondi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial

(2018) Harriet M. Kluger et al.   JOURNAL OF CLINICAL ONCOLOGY

Atezolizumab in patients with advanced non-small cell lung cancer and history of asymptomatic, treated brain metastases: Exploratory analyses of the phase III OAK study

(2018) Shirish M. Gadgeel et al.   LUNG CANCER

Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial

(2017) Paul D Brown et al.   LANCET ONCOLOGY

Dabrafenib plus trametinib in patients with BRAF V600 -mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial

(2017) Michael A Davies et al.   LANCET ONCOLOGY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study

(2017) Daniel N Cagney et al.   NEURO-ONCOLOGY

Effect of Whole Brain Radiation Therapy on Cognitive Function

(2017) Julia R. Schneider et al.   NEUROSURGERY

Alectinib versus Crizotinib in Untreated ALK-Positive Non–Small-Cell Lung Cancer

(2017) Solange Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis

(2017) Nayan Lamba et al.   Radiation Oncology

Brain Metastases in Newly Diagnosed Breast Cancer

(2017) Allison M. Martin et al.   JAMA Oncology

Separation Surgery for Spinal Metastases: Effect of Spinal Radiosurgery on Surgical Treatment Goals

(2017) Nelson Moussazadeh et al.   Cancer Control

Vemurafenib in Metastatic Melanoma Patients with Brain Metastases: An Open-Label, Single-Arm, Phase 2, Multicentre Study

(2016) GA McArthur et al.   ANNALS OF ONCOLOGY

Systematic review: brain metastases from colorectal cancer—Incidence and patient characteristics

(2016) Troels Dreier Christensen et al.   BMC CANCER

Risk of brain metastases in patients with nonmetastatic lung cancer: Analysis of the Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) data

(2016) Priscila H. Goncalves et al.   CANCER

Survival of patients with metastatic melanoma and brain metastases in the era of MAP-kinase inhibitors and immunologic checkpoint blockade antibodies: A systematic review

(2016) Francesco Spagnolo et al.   CANCER TREATMENT REVIEWS

Burden of illness for metastatic melanoma in Canada, 2011–2013

(2016) D.S. Ernst et al.   Current Oncology

Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis

(2016) Giuseppe Minniti et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial

(2016) Sarah B Goldberg et al.   LANCET ONCOLOGY

Spinal Laser Interstitial Thermal Therapy

(2016) Claudio E. Tatsui et al.   NEUROSURGERY

The Spinal Instability Neoplastic Score

(2016) Anne L. Versteeg et al.   SPINE

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

(2016) P.-L. Chen et al.   Cancer Discovery

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of minimally invasive surgery with standard open surgery for vertebral thoracic metastases causing acute myelopathy in patients with short- or mid-term life expectancy: surgical technique and early clinical results

(2015) Massimo Miscusi et al.   JOURNAL OF NEUROSURGERY-SPINE

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

(2015) P. K. Brastianos et al.   Cancer Discovery

Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment

(2015) J. V. Cohen et al.   Cancer Immunology Research

Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient

(2015) Nu T. Lu et al.   Journal for ImmunoTherapy of Cancer

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

(2014) Vinai Gondi et al.   JOURNAL OF CLINICAL ONCOLOGY

Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study

(2014) Masaaki Yamamoto et al.   LANCET ONCOLOGY

Pemetrexed and cisplatin combination with concurrent whole brain radiotherapy in patients with brain metastases of lung adenocarcinoma: a single-arm phase II clinical trial

(2013) Xiao-xiao Dinglin et al.   JOURNAL OF NEURO-ONCOLOGY

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

The NOMS Framework: Approach to the Treatment of Spinal Metastatic Tumors

(2013) I. Laufer et al.   ONCOLOGIST

Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases

(2012) Diana Steinmann et al.   BMC CANCER

Management of Brain Metastases

(2012) Toral R. Patel et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial

(2012) Georgina V Long et al.   LANCET ONCOLOGY

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

(2011) Paul W. Sperduto et al.   JOURNAL OF CLINICAL ONCOLOGY

Central nervous system metastases from castration-resistant prostate cancer in the docetaxel era

(2011) Orazio Caffo et al.   JOURNAL OF NEURO-ONCOLOGY

The biology of brain metastases—translation to new therapies

(2011) April F. Eichler et al.   Nature Reviews Clinical Oncology

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Corticosteroids in brain cancer patients: benefits and pitfalls

(2011) Jörg Dietrich et al.   Expert Review of Clinical Pharmacology

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Intraoperative magnetic resonance imaging in the surgical treatment of cerebral metastases

(2010) Christian Senft et al.   JOURNAL OF SURGICAL ONCOLOGY

Intrathecal chemotherapy for treatment of leptomeningeal dissemination of metastatic tumours

(2010) Patrick Beauchesne   LANCET ONCOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Leptomeningeal metastases in the MRI era

(2010) J. L. Clarke et al.   NEUROLOGY

Epidemiology of Metastatic Brain Tumors

(2010) Benjamin D. Fox et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Classification System for Spinal Instability in Neoplastic Disease

(2010) Charles G. Fisher et al.   SPINE

Intrathecal trastuzumab and thiotepa for leptomeningeal spread of breast cancer

(2009) C. Ferrario et al.   ANNALS OF ONCOLOGY

Brain Metastases from Colorectal Cancer: Risk Factors, Incidence, and the Possible Role of Chemokines

(2009) John P. Mongan et al.   Clinical Colorectal Cancer

Solitary metastases and high-grade gliomas: radiological differentiation by morphometric analysis and perfusion-weighted MRI

(2009) B. Hakyemez et al.   CLINICAL RADIOLOGY

The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline

(2009) Tom Mikkelsen et al.   JOURNAL OF NEURO-ONCOLOGY

The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline

(2009) Timothy C. Ryken et al.   JOURNAL OF NEURO-ONCOLOGY

Quality of Life in Brain Metastases Radiation Trials: A Literature Review

(2008) Edward Chow et al.   Current Oncology

Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1–3 brain metastases: Results of a matched pair analysis

(2008) Dirk Rades et al.   EUROPEAN JOURNAL OF CANCER

Metastatic epidural spinal cord compression

(2008) John S Cole et al.   LANCET NEUROLOGY

Brain and leptomeningeal metastases from cutaneous melanoma: Survival outcomes based on clinical features

(2008) Jeffrey J. Raizer et al.   NEURO-ONCOLOGY

Minimally Invasive Management of Spinal Metastases

(2008) Onder Ofluoglu   ORTHOPEDIC CLINICS OF NORTH AMERICA

Outcome of Treatment for Spinal Metastases Using Scoring System for Preoperative Evaluation of Prognosis

(2008) Yasuaki Tokuhashi et al.   SPINE