Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes

TGFβ family signaling and development

(2021) Shunji Jia et al.   DEVELOPMENT

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

(2020) Peng Gao et al.   GENES & DEVELOPMENT

RUNX1 regulates TGF-β induced migration and EMT in colorectal cancer

(2020) Chenghao Lu et al.   PATHOLOGY RESEARCH AND PRACTICE

Endothelial-to-haematopoietic transition: an update on the process of making blood

(2019) Katrin Ottersbach   BIOCHEMICAL SOCIETY TRANSACTIONS

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis

(2018) Amanda D. Yzaguirre et al.   DEVELOPMENT

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition

(2018) Roshana Thambyrajah et al.   Stem Cell Reports

Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ

(2018) Tong Zhou et al.   EBioMedicine

BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test

(2018) Ahrim Youn et al.   NUCLEIC ACIDS RESEARCH

Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1

(2017) Lu Qi et al.   JOURNAL OF NEUROSCIENCE

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate

(2016) Nadine Obier et al.   DEVELOPMENT

Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells

(2016) Rui Monteiro et al.   DEVELOPMENTAL CELL

Hematopoietic (stem) cell development - how divergent are the roads taken?

(2016) Mari-Liis Kauts et al.   FEBS LETTERS

The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development

(2016) Alexia Eliades et al.   Cell Reports

Generation and Analysis of GATA2 w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis

(2016) Ke Huang et al.   Stem Cell Reports

Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling

(2016) Jennifer J. VanOudenhove et al.   Stem Cell Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence

(2014) M. Lie-A-Ling et al.   BLOOD

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Haemogenic endocardium contributes to transient definitive haematopoiesis

(2013) Haruko Nakano et al.   Nature Communications

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

(2012) C. Lancrin et al.   BLOOD

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

(2012) Monika Lichtinger et al.   EMBO JOURNAL

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

(2012) A Sundqvist et al.   ONCOGENE

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development

(2011) C. Ferreras et al.   BLOOD

TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy

(2011) Chengyan Wang et al.   CELL RESEARCH

Quantitative analysis of transient and sustained transforming growth factor-  signaling dynamics

(2011) Z. Zi et al.   Molecular Systems Biology

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

(2008) Àlex Robert-Moreno et al.   EMBO JOURNAL