Vitamin E: How much is enough, too much and why!

Lipid peroxidation products as a mediator of toxicity and adaptive response – The regulatory role of selenoprotein and vitamin E

(2021) Yoshiro Saito   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Expanding role of vitamin E in protection against metabolic dysregulation: Insights gained from model systems, especially the developing nervous system of zebrafish embryos

(2021) Brian Head et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E Promotes the Inverse Hexagonal Phase via a Novel Mechanism: Implications for Antioxidant Role

(2020) Paul E. Harper et al.   LANGMUIR

First Recognized Patient with Genetic Vitamin E Deficiency Stable after 36 Years of Controlled Supplement Therapy

(2020) Alfried Kohlschütter et al.   Neurodegenerative Diseases

Vitamin E is necessary for zebrafish nervous system development

(2020) Brian Head et al.   Scientific Reports

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

(2020) Maren C. Podszun et al.   Redox Biology

Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases

(2020) Ayana Suzumura et al.   Antioxidants

A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease

(2020) Fatima Tuj Johra et al.   Antioxidants

Chylomicron retention disease

(2019) Emile Levy et al.   CURRENT OPINION IN LIPIDOLOGY

The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease

(2019) Ana Lloret et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

(2019) Valérie Clermont et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Normal serum ApoB48 and red cells vitamin E concentrations after supplementation in a novel compound heterozygous case of abetalipoproteinemia

(2019) Mathilde Di Filippo et al.   ATHEROSCLEROSIS

Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality: A 30-Year Prospective Cohort Analysis

(2019) Jiaqi Huang et al.   CIRCULATION RESEARCH

Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design

(2019) Maret G Traber et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fat soluble vitamins deficiency in pediatric chronic liver disease: The impact of liver transplantation

(2019) Silvio Veraldi et al.   DIGESTIVE AND LIVER DISEASE

Processed and ultra-processed foods are associated with high prevalence of inadequate selenium intake and low prevalence of vitamin B1 and zinc inadequacy in adolescents from public schools in an urban area of northeastern Brazil

(2019) Raphaela Cecília Thé Maia de Arruda Falcão et al.   PLoS One

Key Pathways and Regulators of Vitamin K Function and Intermediary Metabolism

(2018) Martin J. Shearer et al.   Annual Review of Nutrition

Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease

(2018) Charlotte Cuerq et al.   JOURNAL OF LIPID RESEARCH

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

OUP accepted manuscript

(2018)   JOURNAL OF NUTRITION

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

(2018) Helmut Pein et al.   Nature Communications

Dietary vitamin and carotenoid intake and risk of age-related cataract

(2018) Hong Jiang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

ω-Hydroxylation of α-tocopheryl quinone reveals a dual function for cytochrome P450-4F2 in vitamin E metabolism

(2018) Luke Taylor et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival

(2018) Mackenzie L. Hagan et al.   CALCIFIED TISSUE INTERNATIONAL

Vitamin E: Regulatory Role on Signal Transduction

(2018) Jean-Marc Zingg   IUBMB LIFE

Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte

(2018) Emmanuelle Reboul   IUBMB LIFE

γ-Tocopherol Is Metabolized Faster than α-Tocopherol in Young Japanese Women

(2018) Tomono UCHIDA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome

(2018) Maret G. Traber et al.   Redox Biology

Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of lipotoxicity in fatty liver subjects

(2018) Pierangelo Torquato et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism

(2017) Melissa McDougall et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E: Emerging aspects and new directions

(2017) Francesco Galli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alpha tocopherol transfer protein (αTTP) is expressed in endometrial carcinoma and is correlated with FIGO stage and 5-year survival

(2017) Sabine Heublein et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Why Vitamin E Therapy Fails for Treatment of Alzheimer's Disease

(2017) Gregory J. Brewer   JOURNAL OF ALZHEIMERS DISEASE

A review of the mechanisms of cone degeneration in retinitis pigmentosa

(2016) Daniel S. Narayan et al.   ACTA OPHTHALMOLOGICA

Antioxidants, oxidants, and redox impacts on cell function — A tribute to Helmut Sies —

(2016) Enrique Cadenas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites

(2016) Amit Mahipal et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein

(2016) Stacey Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma lipid oxidation induced by peroxynitrite, hypochlorite, lipoxygenase and peroxyl radicals and its inhibition by antioxidants as assessed by diphenyl-1-pyrenylphosphine

(2016) Mayuko Morita et al.   Redox Biology

α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults

(2015) Maret G Traber et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

 -Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial

(2015) E. Mah et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

α-Tocopherol Is Well Designed to Protect Polyunsaturated Phospholipids: MD Simulations

(2015) Xiaoling Leng et al.   BIOPHYSICAL JOURNAL

Nonalcoholic fatty liver disease

(2015) Timothy Hardy et al.   CURRENT OPINION IN GASTROENTEROLOGY

Methods for determining the efficacy of radical-trapping antioxidants

(2015) Bo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Changes in the concentrations of vitamin E analogs and their metabolites in rat liver and kidney after oral administration

(2015) Chikako Kiyose et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: A meta-analysis of randomized controlled trials

(2015) Ken Sato et al.   NUTRITION

Current pharmacological therapies for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2015) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh

(2014) Abu Ahmed Shamim et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Brown Bowel Syndrome: A Rare Complication in Diseases Associated with Long-Standing Malabsorption

(2014) Heinz Albrecht et al.   DIGESTION

Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy

(2014) Qing Jiang   FREE RADICAL BIOLOGY AND MEDICINE

Cold Fluorescent Light as Major Inducer of Lipid Oxidation in Soybean Oil Stored at Household Conditions for Eight Weeks

(2014) Marc Pignitter et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Retinitis pigmentosa and macular degeneration in a patient with ataxia with isolated vitamin E deficiency with a novel c.717 del C mutation in the TTPA gene

(2014) Kazuo Iwasa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion

(2014) Sherry M. Farley et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intracellular Transport of Fat-Soluble Vitamins A and E

(2014) Nozomu Kono et al.   TRAFFIC

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine

(2014) Shotaro Uehara et al.   XENOBIOTICA

Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients

(2014) Pierre Delanaye et al.   BMC Nephrology

Vitamin E Inadequacy in Humans: Causes and Consequences

(2014) Maret G. Traber   Advances in Nutrition

Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies

(2013) Yu-Hong Cui et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

(2013) Stephen P. Fortmann et al.   ANNALS OF INTERNAL MEDICINE

Molecular, clinical and peripheral neuropathy study of Tunisian patients with ataxia with vitamin E deficiency

(2013) Ghada El Euch-Fayache et al.   BRAIN

Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration

(2013)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mechanisms for the prevention of vitamin E excess

(2013) Maret G. Traber   JOURNAL OF LIPID RESEARCH

Vitamin E is essential for Purkinje neuron integrity

(2013) L. Ulatowski et al.   NEUROSCIENCE

Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?

(2013) Goran Bjelakovic et al.   PLoS One

Impaired  -TTP-PIPs Interaction Underlies Familial Vitamin E Deficiency

(2013) N. Kono et al.   SCIENCE

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

(2013) S.-K. Myung et al.   BMJ-British Medical Journal

Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study

(2012) Katie M Lebold et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

(2012) Martijn L.L. Chatrou et al.   BLOOD REVIEWS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Urinary conjugated α-tocopheronolactone—a biomarker of oxidative stress in children with type 1 diabetes

(2012) Gayatri Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14Gene) Causes Severe Perturbations in Vitamin E Metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF LIPID RESEARCH

Circulating Phylloquinone Concentrations of Adults in the United States Differ According to Race and Ethnicity

(2012) M. Kyla Shea et al.   JOURNAL OF NUTRITION

This Kinetic, Bioavailability, and Metabolism Study of RRR-α-Tocopherol in Healthy Adults Suggests Lower Intake Requirements than Previous Estimates

(2012) Janet A. Novotny et al.   JOURNAL OF NUTRITION

Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women

(2012) Geertje W. Dalmeijer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone

(2012) Sherry M. Farley et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

(2012) Galen W. Miller et al.   PLoS One

Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies

(2011) Emmanuelle Reboul et al.   BRITISH JOURNAL OF NUTRITION

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Role for α-Tocopherol Transfer Protein (α-TTP) in Protecting against Chloroquine Toxicity

(2011) Mototada Shichiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitation of [5-CH3]-(2R, 4'R, 8'R)-α-Tocopherol in Humans

(2011) Jennifer C. Chuang et al.   JOURNAL OF NUTRITION

Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging

(2011) G. L. Bowman et al.   NEUROLOGY

Promotion of plasma membrane repair by vitamin E

(2011) Amber C. Howard et al.   Nature Communications

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

(2010) Katie M. Lebold et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Vitamin E protection in the biochemical adaptation of marine organisms to cold-water environments

(2010) Akio Fujisawa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-ω-Hydroxylase Specific Activity

(2010) Sabrina A. Bardowell et al.   JOURNAL OF NUTRITION

The location and behavior of α-tocopherol in membranes

(2010) Jeffrey Atkinson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A novel method for the direct measurement of urinary conjugated metabolites of α-tocopherol and its use in diabetes

(2010) Gayatri Sharma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ataxia with vitamin E deficiency: update of molecular diagnosis

(2010) I. Di Donato et al.   NEUROLOGICAL SCIENCES

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin E and Age-Related Macular Degeneration in a Randomized Trial of Women

(2010) William G. Christen et al.   OPHTHALMOLOGY

Reexamination of a Meta-Analysis of the Effect of Antioxidant Supplementation on Mortality and Health in Randomized Trials

(2010) Hans K. Biesalski et al.   Nutrients

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality

(2009) Donald Berry et al.   Clinical Trials

α-tocopherol β-oxidation localized to rat liver mitochondria

(2009) Debbie J. Mustacich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

(2009) Joo-Youn Cho et al.   JOURNAL OF LIPID RESEARCH

Rate Constants for Peroxidation of Polyunsaturated Fatty Acids and Sterols in Solution and in Liposomes

(2009) Libin Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis, regulation and functions of tocochromanols in plants

(2009) Laurent Mène-Saffrané et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Expression of CYP4F2 in human liver and kidney: Assessment using targeted peptide antibodies

(2008) Vandana Hirani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Immunohistochemical localization of α-tocopherol transfer protein and lipoperoxidation products in human first-trimester and term placenta

(2008) Daisy E. Rotzoll et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin E Transfer from Lipid Emulsions to Plasma Lipoproteins: Mediation by Multiple Mechanisms

(2008) M. Hacquebard et al.   LIPIDS

Niemann-Pick C1-Like 1 Mediates  -Tocopherol Transport

(2008) K. Narushima et al.   MOLECULAR PHARMACOLOGY

Abetalipoproteinemia: two case reports and literature review

(2008) Rola Zamel et al.   Orphanet Journal of Rare Diseases

Tocopherols and tocotrienols in membranes: A critical review

(2007) Jeffrey Atkinson et al.   FREE RADICAL BIOLOGY AND MEDICINE